Design and therapeutic application of matrix metalloproteinase inhibitors.

Combinatorial screening of electrochemical catalysts by current-voltage methods can be unwieldy for large sample sizes. By converting the ions generated in an electrochemical half-cell reaction to a fluorescence signal, the most active compositions in a large electrode array have been identified. A fluorescent acid-base indicator was used to image high concentrations of hydrogen ions, which were generated in the electrooxidation of methanol. A 645-member electrode array containing five elements (platinum, ruthenium, osmium, iridium, and rhodium), 80 binary, 280 ternary, and 280 quaternary combinations was screened to identify the most active regions of phase space. Subsequent “zoom” screens pinpointed several very active compositions, some in ternary and quaternary regions that were bounded by rather inactive binaries. The best catalyst, platinum(44)/ruthenium(41)/osmium(10)/iridium(5) (numbers in parentheses are atomic percent), was significantly more active than platinum(50)/ruthenium(50) in a direct methanol fuel cell operating at 60°C, even though the latter catalyst had about twice the surface area of the former.

https://science.sciencemag.org/content/sci/280/5370/1735.full.pdf

Combinatorial Electrochemistry: A Highly Parallel, Optical Screening Method for Discovery of Better Electrocatalysts

Schiff bases: A short review of their antimicrobial activities

Synthesis of secondary amines

There is provided a nuclear reprogramming factor for a somatic cell, which comprises a gene product of each of the following three kinds of genes: an Oct family gene, a Klf family gene, and a Myc family gene, as a means for inducing reprogramming of a differentiated cell to conveniently and highly reproducibly establish an induced pluripotent stem cell having pluripotency and growth ability similar to those of ES cells without using embryo or ES cell.

David A. Campbell

Papers

Phosphonate Ester Synthesis Using a Modified Mitsunobu Condensation

Trimethylorthoformate: A mild and effective dehydrating reagent for solution and solid phase imine formation

A Transition State Analog Inhibitor Combinatorial Library

Antibody-Catalyzed Prodrug Activation

Solid-Phase Synthesis of Peptidylphosphonates