D
David A. Cooper
Researcher at Pfizer
Publications - 965
Citations - 81765
David A. Cooper is an academic researcher from Pfizer. The author has contributed to research in topics: Acquired immunodeficiency syndrome (AIDS) & Viral load. The author has an hindex of 117, co-authored 903 publications receiving 69249 citations. Previous affiliations of David A. Cooper include Boston Children's Hospital & National Institutes of Health.
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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera.
Xuping Xie,Yang Liu,Jianying Liu,Xianwen Zhang,Jing Zou,Camila R. Fontes-Garfias,Hongjie Xia,Kena A. Swanson,Mark Cutler,David A. Cooper,Vineet D. Menachery,Scott C. Weaver,Philip R. Dormitzer,Pei Yong Shi +13 more
TL;DR: In this paper, three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants were engineered.
Journal ArticleDOI
The gastrointestinal manifestations of AIDS.
TL;DR: Results from this series reveal a wide range of infectious pathogens: viral (Cytomegalovirus, Herpes simplex), bacterial (Mycobacterium avium intracellulare) and parasitic (Cryptosporidium, Isospora belli).
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Sulphadiazine desensitization in patients with AIDS and cerebral toxoplasmosis.
Melinda Tenant-Flowers,MJ Boyle,Dianne Carey,Deborah Marriott,John Harkness,Ronald Penny,David A. Cooper +6 more
TL;DR: The sulphadiazine regimen rapidly, successfully and safely desensitized patients with CT and sulphonamide allergy, allowing the optimal first-line treatment to continue.
Journal ArticleDOI
Nevirapine plasma concentrations and concomitant use of rifampin in patients coinfected with HIV-1 and tuberculosis.
Reshma Saskia Autar,Ferdinand W. N. M. Wit,Jongkol Sankote,Apicha Mahanontharit,Thanomsak Anekthananon,Piroon Mootsikapun,Khanjtta Sujaikaew,David A. Cooper,Joep M. A. Lange,Praphan Phanuphak,Kiat Ruxrungtham,David M. Burger +11 more
TL;DR: The results suggest that from a pharmacological point of view the majority of Thai coinfected patients, who have low BMIs, reach nevirapine plasma concentrations that are adequate for treatment of HIV, however this can only be undertaken if nevirAPine plasma concentration monitoring is available and can be closely followed.
Journal ArticleDOI
Increased Turnover of CCR5+ and Redistribution of CCR5− CD4 T Lymphocytes during Primary Human Immunodeficiency Virus Type 1 Infection
John Zaunders,Gilbert R. Kaufmann,Philip Cunningham,Don Smith,Pat Grey,Kazuo Suzuki,Andrew Carr,Li-Ean Goh,David A. Cooper +8 more
TL;DR: After antiretroviral therapy, Ki-67- CCR5- CD4 T cell counts rapidly increased in the circulation, which suggests that the initial decrease was due to an alteration in trafficking and/or sequestration, which may be impaired in HIV-1 infection.