J
Jianying Liu
Researcher at University of Texas Medical Branch
Publications - 39
Citations - 5197
Jianying Liu is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Neutralization & Medicine. The author has an hindex of 16, co-authored 29 publications receiving 2563 citations.
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Journal ArticleDOI
Spike mutation D614G alters SARS-CoV-2 fitness.
Jessica A. Plante,Yang Liu,Jianying Liu,Hongjie Xia,Bryan A. Johnson,Kumari G. Lokugamage,Xianwen Zhang,Antonio E. Muruato,Jing Zou,Camila R. Fontes-Garfias,Divya Mirchandani,Dionna Scharton,John P. Bilello,Zhiqiang Ku,Zhiqiang An,Birte Kalveram,Alexander N. Freiberg,Vineet D. Menachery,Xuping Xie,Kenneth S. Plante,Scott C. Weaver,Pei Yong Shi +21 more
TL;DR: Hamsters infected with SARS-CoV-2 expressing spike D614G (G614 virus) produced higher infectious titres in nasal washes and the trachea, but not in the lungs, supporting clinical evidence showing that the mutation enhances viral loads in the upper respiratory tract of COVID-19 patients and may increase transmission.
Journal ArticleDOI
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
Rita E. Chen,Xianwen Zhang,James Brett Case,Emma S. Winkler,Yang Liu,Laura A. VanBlargan,Jianying Liu,John M. Errico,Xuping Xie,Naveenchandra Suryadevara,Pavlo Gilchuk,Seth J. Zost,Stephen Tahan,Lindsay Droit,Jackson S. Turner,Wooseob Kim,Aaron J. Schmitz,Mahima Thapa,David Wang,Adrianus C. M. Boon,Rachel M. Presti,Jane A. O’Halloran,Alfred H.J. Kim,Parakkal Deepak,Dora Pinto,Daved H. Fremont,James E. Crowe,Davide Corti,Herbert W. Virgin,Herbert W. Virgin,Ali H. Ellebedy,Pei Yong Shi,Michael S. Diamond +32 more
TL;DR: In this article, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera and human sera from recipients of the BNT162b2 mRNA vaccine, the authors report the impact on antibody neutralization of a panel of authentic SARS-CoV-2 variants including a B.1.7 isolate, chimeric strains with South African or Brazilian spike genes and isogenic recombinant viral variants.
Journal ArticleDOI
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
Xuping Xie,Yang Liu,Jianying Liu,Xianwen Zhang,Jing Zou,Camila R. Fontes-Garfias,Hongjie Xia,Kena A. Swanson,Mark Cutler,David A. Cooper,Vineet D. Menachery,Scott C. Weaver,Philip R. Dormitzer,Pei Yong Shi +13 more
TL;DR: In this paper, three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70 deletion + N 501Y+D614G from UK; and E484K from SA.
Journal ArticleDOI
An infectious cDNA clone of SARS-CoV-2
Xuping Xie,Antonio E. Muruato,Kumari G. Lokugamage,Krishna Narayanan,Xianwen Zhang,Jing Zou,Jianying Liu,Craig Schindewolf,Nathen E. Bopp,Patricia V. Aguilar,Kenneth S. Plante,Scott C. Weaver,Shinji Makino,James W. LeDuc,Vineet D. Menachery,Pei Yong Shi +15 more
TL;DR: The reverse genetic system and reporter virus provide key reagents to study SARS-CoV-2 and develop countermeasures and were successfully used to evaluate the antiviral activities of interferon (IFN).
Journal ArticleDOI
Neutralizing Activity of BNT162b2-Elicited Serum.
Yang Liu,Jianying Liu,Hongjie Xia,Xianwen Zhang,Camila R. Fontes-Garfias,Kena A. Swanson,Hui Cai,Ritu Sarkar,Wei Chen,Mark Cutler,David A. Cooper,Scott C. Weaver,Alexander Muik,Ugur Sahin,Kathrin U. Jansen,Xuping Xie,Philip R. Dormitzer,Pei Yong Shi +17 more
TL;DR: In this paper, the BNT162b2 vaccine was shown to neutralize the P.1.1, B.1., B.7, and B.135 lineages of SARS-CoV-2.