D
David A. Levison
Researcher at University of Dundee
Publications - 44
Citations - 4010
David A. Levison is an academic researcher from University of Dundee. The author has contributed to research in topics: Gene mutation & Proliferating cell nuclear antigen. The author has an hindex of 27, co-authored 44 publications receiving 3947 citations. Previous affiliations of David A. Levison include Guy's Hospital & Ninewells Hospital.
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Journal ArticleDOI
Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms
Peter A. Hall,David A. Levison,A. L. Woods,C. C.-W. Yu,D. B. Kellock,J. A. Watkins,Diana M. Barnes,Cheryl Gillett,Richard Camplejohn,Robin Dover,N. H. Waseem,David P. Lane +11 more
TL;DR: Data suggest that in normal tissues and lymphoid neoplasms, PCNA immunolocalization can be used as an index of cell proliferation, however, in some forms of neoplasia, including breast and gastric cancer and in vitro cell lines, the simple relation between PCNA expression and cell proliferation is lost.
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The assessment of cellular proliferation by immunohistochemistry: a review of currently available methods and their applications.
TL;DR: Immunohistochemical methods using antibodies to cell cycle-related antigens may be used as a means of assessing various aspects of proliferation in tissue, and have the important advantage of preserving the spatial orientation of proliferating cells in histological sections.
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Immunohistochemical detection of p53 protein in mammary carcinoma: An important new independent indicator of prognosis?
TL;DR: Cox multivariate analysis shows that p53 majority staining is second only to node status in significance of effect on overall survival in patients with carcinomas who express p53 protein in the majority of their tumor cells.
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Prognostic value of proliferating cell nuclear antigen in gastric carcinoma
TL;DR: The ability of semiquantitative PCNA grading to allow for intra-tumoural variation suggests it may have advantages over absolute counting, which is prone to sampling error when tumour heterogeneity is a major factor.
Journal ArticleDOI
Atrophy and apoptosis in the cyclical human endometrium.
D. Hop Wood,David A. Levison +1 more
TL;DR: Electron microscopy of human cyclical endometrium indicates that there is considerable loss of gland epithelial cells with formation of apoptotic bodies in the late secretory, premenstrual and menstrual phases, but also to a lesser extent in the proliferative phase.