D
David Baker
Researcher at Leiden University Medical Center
Publications - 16
Citations - 1009
David Baker is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Carcinogenesis & Signal transduction. The author has an hindex of 10, co-authored 13 publications receiving 590 citations.
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Journal ArticleDOI
TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
TL;DR: The role of TGF-β signaling in cell cycle arrest, apoptosis, EMT and cancer cell metastasis is considered and recent insights into the multistep and dynamically controlled process of T GF-β-induced EMT are highlighted.
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Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?
TL;DR: Support is provided for the idea that EMT-TFs contribute to the development of resistance against cancer therapy and how EMT -TFs might be targeted to advance novel therapeutic approaches to the treatment of cancer.
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The therapeutic potential of targeting the endothelial-to-mesenchymal transition
TL;DR: Current models of EndMT are considered, how manipulation of this process might improve treatment of clinically important pathologies and how it could be harnessed to advance regenerative medicine and tissue engineering are considered.
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Control of endothelial sprouting by a Tel-CtBP complex
M. Guy Roukens,Mariam Alloul-Ramdhani,Bart Baan,Kazuki Kobayashi,Josi Peterson-Maduro,Hans van Dam,Stefan Schulte-Merker,David Baker +7 more
TL;DR: It is shown that the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system.
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TGF-β Family Signaling Pathways in Cellular Dormancy
TL;DR: Recent findings are summarized which support the view that TGF-β family signaling pathways play a pivotal role in cellular dormancy, and how affected cells could be therapeutically targeted to prevent cancer relapse.