D
David Dzamba
Researcher at Academy of Sciences of the Czech Republic
Publications - 16
Citations - 662
David Dzamba is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Glutamate receptor & Mutation (genetic algorithm). The author has an hindex of 9, co-authored 16 publications receiving 546 citations. Previous affiliations of David Dzamba include Charles University in Prague.
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Journal ArticleDOI
The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia
Olena Butenko,Olena Butenko,David Dzamba,David Dzamba,Jana Benesova,Jana Benesova,Pavel Honsa,Pavel Honsa,Valentina Benfenati,Vendula Rusnakova,Stefano Ferroni,Miroslava Anderova +11 more
TL;DR: It is shown that TRPV4 channels are involved in ischemia-induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult.
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Heterogeneity of Astrocytes: From Development to Injury – Single Cell Gene Expression
Vendula Rusnakova,Pavel Honsa,David Dzamba,Anders Ståhlberg,Mikael Kubista,Miroslava Anderova +5 more
TL;DR: To unravel astrocyte heterogeneity during postnatal development and after focal cerebral ischemia, single-cell gene expression profiling was employed in acutely isolated cortical GFAP/EGFP-positive cells to gain insight into the role of glial markers and ion channels/transporters/receptors in maintaining K+ and glutamate homeostasis per cell.
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Glial Cells - The Key Elements of Alzheimer´s Disease.
TL;DR: This review summarizes recent findings regarding the role/participation of glial cells in pathogenesis of AD, focusing on changes in their morphology, functions, proteins and gene expression profiles and considers the participation of oligodendrocytes in the pathogenesis and progression of AD.
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NMDA Receptors in Glial Cells: Pending Questions.
TL;DR: This review provides an overview of glial NMDA receptors with respect to ischemic brain injury and focuses on the NMDA receptor subunits present in the particular glial cell types, which give them special characteristics different from those of neurons.
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Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP mice.
Jana Benesova,Jana Benesova,Vendula Rusnakova,Pavel Honsa,Pavel Honsa,Helena Pivonkova,Helena Pivonkova,David Dzamba,David Dzamba,Mikael Kubista,Miroslava Anderova +10 more
TL;DR: It is proposed that the diverse volume changes displayed by cortical astrocytes during OGD mainly result from their distinct expression patterns of ClC2 and K2P channels.