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David E. Barton

Researcher at University College Dublin

Publications -  149
Citations -  5931

David E. Barton is an academic researcher from University College Dublin. The author has contributed to research in topics: Gene & Population. The author has an hindex of 42, co-authored 149 publications receiving 5629 citations. Previous affiliations of David E. Barton include Massachusetts Institute of Technology & McGill University.

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Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy

TL;DR: Southern blot analysis of genomic DNA from humans and rodents revealed a simple pattern compatible with a single-copy gene in humoral hypercalcemia of malignancy, and the gene has been mapped to chromosome 12.
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Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

TL;DR: The level of MGSA mRNA in melanoma cells is strongly elevated by treatment with MGSA, and the gene product of a recently detected gene gro was mapped to chromosome 4 (region q13––q21).
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A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.

TL;DR: The amino acid sequence deduced from the nucleotide sequence of the Pmel 17 cDNA showed that the protein is composed of 645 amino acids with a molecular weight of 68,600, which indicates that this may be a membrane-associated protein in melanocytes.
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Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.

TL;DR: Comparison of the genetic maps of human chromosomes 11 and mouse chromosome 7 leads to hypotheses regarding the evolution of human chromosome 11, and confirmed the localization of the tyrosinase gene in the mouse at or near the c locus on chromosome 7.