D
David E. Barton
Researcher at University College Dublin
Publications - 149
Citations - 5931
David E. Barton is an academic researcher from University College Dublin. The author has contributed to research in topics: Gene & Population. The author has an hindex of 42, co-authored 149 publications receiving 5629 citations. Previous affiliations of David E. Barton include Massachusetts Institute of Technology & McGill University.
Papers
More filters
Journal ArticleDOI
Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy
Marguerite Mangin,A C Webb,Barbara E. Dreyer,J T Posillico,Kyoji Ikeda,Eleanor C. Weir,Aisling Stewart,Neil H. Bander,Leonard M. Milstone,David E. Barton +9 more
TL;DR: Southern blot analysis of genomic DNA from humans and rodents revealed a simple pattern compatible with a single-copy gene in humoral hypercalcemia of malignancy, and the gene has been mapped to chromosome 12.
Journal ArticleDOI
Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.
Ann Richmond,E. Balentien,H. G. Thomas,G. Flaggs,David E. Barton,J. Spiess,R. Bordoni,U. Francke,Rik Derynck +8 more
TL;DR: The level of MGSA mRNA in melanoma cells is strongly elevated by treatment with MGSA, and the gene product of a recently detected gene gro was mapped to chromosome 4 (region q13––q21).
Journal ArticleDOI
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility
Anja T. Rovio,D.R. Marchington,Susanne Donat,Hans-Christian Schuppe,Josef Abel,Ellen Fritsche,David J. Elliott,Pekka Laippala,Arja L. Ahola,David McNay,Robert F. Harrison,Barbara Hughes,Thomas Barrett,Thomas Barrett,David Bailey,David Bailey,Denise Mehmet,Anne M. Jequier,Tim B. Hargreave,Shu Huei Kao,James M. Cummins,David E. Barton,Howard J. Cooke,Yau-Huei Wei,Lars Wichmann,Joanna Poulton,Howard T. Jacobs +26 more
TL;DR: Human mitochondrial DNA polymerase, encoded by POLG, contains a polyglutamine tract encoded by a CAG microsatellite repeat that is associated with male infertility typified by a range of sperm quality defects but excluding azoospermia.
Journal ArticleDOI
A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.
Byoung S. Kwon,Chaya D. Chintamaneni,Christine A. Kozak,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,David E. Barton,U. Francke,Yvonne M. Kobayashi,Kack K. Kim +9 more
TL;DR: The amino acid sequence deduced from the nucleotide sequence of the Pmel 17 cDNA showed that the protein is composed of 645 amino acids with a molecular weight of 68,600, which indicates that this may be a membrane-associated protein in melanocytes.
Journal ArticleDOI
Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.
TL;DR: Comparison of the genetic maps of human chromosomes 11 and mouse chromosome 7 leads to hypotheses regarding the evolution of human chromosome 11, and confirmed the localization of the tyrosinase gene in the mouse at or near the c locus on chromosome 7.