D
David E. Krysztof
Researcher at American Red Cross
Publications - 36
Citations - 2109
David E. Krysztof is an academic researcher from American Red Cross. The author has contributed to research in topics: Hepatitis B virus & Virus. The author has an hindex of 18, co-authored 32 publications receiving 1870 citations. Previous affiliations of David E. Krysztof include National Institutes of Health.
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Journal ArticleDOI
Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity
Susana V. Bardina,Paul Bunduc,Shashank Tripathi,James Duehr,Justin J. Frere,Julia A. Brown,Raffael Nachbagauer,Gregory A. Foster,David E. Krysztof,Domenico Tortorella,Susan L. Stramer,Adolfo García-Sastre,Florian Krammer,Jean K. Lim +13 more
TL;DR: Using convalescent plasma from DENV- and WNV-infected individuals, substantial enhancement of ZIKV infection in vitro was found that was mediated through immunoglobulin G engagement of Fcγ receptors, highlighting the need to exert great caution when designing flavivirus vaccines.
Journal ArticleDOI
Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing
Shimian Zou,Kerri Dorsey,Edward P. Notari,Gregory A. Foster,David E. Krysztof,Fatemeh Musavi,Roger Y. Dodd,Susan L. Stramer +7 more
TL;DR: This study analyzes temporal trends of these two infections since NAT introduction into blood donation screening in the United States in 1999.
Journal ArticleDOI
Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man
Jean K. Lim,Andrea Lisco,David H. McDermott,Linda Huynh,Jerrold M. Ward,Bernard Johnson,Hope Johnson,John Pape,Gregory A. Foster,David E. Krysztof,Dean Follmann,Susan L. Stramer,Leonid Margolis,Philip M. Murphy +13 more
TL;DR: OAS1 SNP rs10774671 is identified as a host genetic risk factor for initial infection with WNV in humans and tested the effect of this SNP on viral replication in a novel ex vivo model of WNV infection in primary human lymphoid tissue.
Journal ArticleDOI
Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico
Susan L. Stramer,Jeffrey M. Linnen,James M. Carrick,Gregory A. Foster,David E. Krysztof,Shimian Zou,Roger Y. Dodd,Lourdes M. Tirado-Marrero,Elizabeth Hunsperger,Gilberto A. Santiago,Jorge L. Muñoz-Jordán,Kay M. Tomashek +11 more
TL;DR: Blood donations were tested for dengue virus (DENV) RNA and recipients of RNA‐positive donations traced to assess transfusion transmission and no new cases were reported in Puerto Rico in 2007.
Journal ArticleDOI
CCR5 Deficiency Is a Risk Factor for Early Clinical Manifestations of West Nile Virus Infection but not for Viral Transmission
Jean K. Lim,David H. McDermott,Andrea Lisco,Gregory A. Foster,David E. Krysztof,Dean Follmann,Susan L. Stramer,Philip M. Murphy +7 more
TL;DR: CCR5 deficiency is not a riskFactor for WNV infection per se, but it is a risk factor for both early and late clinical manifestations after infection, and CCR5 may function normally to limit disease due to WNV infections in humans.