J
Justin J. Frere
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 31
Citations - 1308
Justin J. Frere is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 13 publications receiving 662 citations. Previous affiliations of Justin J. Frere include University of Arizona & University of Paris.
Papers
More filters
Journal ArticleDOI
Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity
Susana V. Bardina,Paul Bunduc,Shashank Tripathi,James Duehr,Justin J. Frere,Julia A. Brown,Raffael Nachbagauer,Gregory A. Foster,David E. Krysztof,Domenico Tortorella,Susan L. Stramer,Adolfo García-Sastre,Florian Krammer,Jean K. Lim +13 more
TL;DR: Using convalescent plasma from DENV- and WNV-infected individuals, substantial enhancement of ZIKV infection in vitro was found that was mediated through immunoglobulin G engagement of Fcγ receptors, highlighting the need to exert great caution when designing flavivirus vaccines.
Journal ArticleDOI
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Longlong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Yuri Oh,Amanda Jiang,Amanda Jiang,Rasmus Møller,Daisy A. Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Randy A. Albrecht,Wen-Chun Liu,Tristan X. Jordan,Benjamin E. Nilsson-Payant,Ilona Golynker,Justin J. Frere,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Tian Zhang,Roberto Plebani,Roberto Plebani,Mercy Soong,Atiq Nurani,Seongmin Kim,Danni Y. Zhu,Kambez H. Benam,Kambez H. Benam,Girija Goyal,Sarah E. Gilpin,Rachelle Prantil-Baun,Steven P. Gygi,Rani K. Powers,Kenneth E. Carlson,Matthew B. Frieman,Benjamin R. tenOever,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +42 more
TL;DR: In this paper, a microfluidic bronchial-airway-on-a-chip line was used to model the human airway epithelium and pulmonary endothelium to model viral infection, strain-dependent virulence, cytokine production and the recruitment of circulating immune cells.
Journal ArticleDOI
Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity.
Daisy A. Hoagland,Rasmus Møller,Skyler Uhl,Kohei Oishi,Justin J. Frere,Ilona Golynker,Shu Horiuchi,Maryline Panis,Daniel Blanco-Melo,David H. Sachs,Knarik Arkun,Jean K. Lim,Benjamin R. tenOever +12 more
TL;DR: In this paper, the authors investigated the dynamics of the systemic response to SARS-CoV-2 in hamsters by histological analysis and transcriptional profiling, and they found that the antiviral response with intranasal administration of recombinant IFN-I reduced viral disease, prevented transmission, and lowered inflammation in vivo.
Journal ArticleDOI
Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia
Marianna Zazhytska,Albana Kodra,Daisy A. Hoagland,Justin J. Frere,John F. Fullard,Hani J. Shayya,Natalie McArthur,Rasmus Moeller,Skyler Uhl,Arina D. Omer,Max E. Gottesman,Stuart Firestein,Qizhi Gong,Peter Canoll,James E. Goldman,Panos Roussos,Benjamin R. tenOever,Jonathan B. Overdevest,Stavros Lomvardas +18 more
TL;DR: In this paper , the authors show that SARS-CoV-2 infection causes widespread downregulation of olfactory receptors (ORs) and of their signaling components, followed by a dramatic reorganization of the neuronal nuclear architecture, which results in dissipation of genomic compartments harboring OR genes.
Journal ArticleDOI
Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy
Julia A. Brown,Gursewak Singh,Joshua A. Acklin,Silviana Lee,James Duehr,Anupa Chokola,Justin J. Frere,Kevin W. Hoffman,Gregory A. Foster,David E. Krysztof,Richard Cadagan,Adam Jacobs,Susan L. Stramer,Florian Krammer,Adolfo García-Sastre,Jean K. Lim +15 more
TL;DR: The presence of DENV‐specific antibodies in ZIKV‐infected pregnant mice significantly increased placental damage, fetal growth restriction, and fetal resorption and was associated with enhanced viral replication in the placenta that coincided with an increased frequency of infected trophoblasts.