D
David F. Richards
Researcher at King's College London
Publications - 50
Citations - 4619
David F. Richards is an academic researcher from King's College London. The author has contributed to research in topics: Cytokine & Interleukin 10. The author has an hindex of 28, co-authored 50 publications receiving 4386 citations. Previous affiliations of David F. Richards include Guy's Hospital & University of Cambridge.
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Journal ArticleDOI
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
Lynette D. Fairbanks,K Ruckemann,Y Qiu,Catherine M. Hawrylowicz,David F. Richards,Ramasamyiyer Swaminathan,B Kirschbaum,H. A. Simmonds +7 more
TL;DR: In this paper, low-dose methotrexate (MTX) was shown to be cytostatic not cytotoxic, halting proliferation at G(1), which was associated with an inhibition of purine ribonucleotide synthesis but a stimulation of pyrimidine biosynthesis.
Journal ArticleDOI
Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists.
Emma Peek,David F. Richards,Alexander Faith,Paul Lavender,Tak H. Lee,Christopher Corrigan,Catherine M. Hawrylowicz +6 more
TL;DR: Fluticasone proprionate and salmeterol increased IL-10 and reduced Th2 cytokine synthesis additively in allergen stimulated human CD4+ T cells and demonstrated an additive effect on this pattern of cytokine production.
Journal ArticleDOI
Neonatal IgE: a poor screen for atopic disease.
TL;DR: IgE at 7 days is comparable to and more reliable than cord IgE, however, neonatal IgE screening is too insensitive to have clinical application.
Book
Dental Recall. Recall Interval between Routine Dental Examinations
Helen V Worthington,Nigel Pitts,Paul Batchelor,Jan E Clarkson,Clare Davenport,R M Davies,Karen Elley,Stephen Fayle,E. Grey,K. Harley,S. Hawksworth,M. Lewis,P. Lowndes,M. Mulcahy,David F. Richards,R. Seppings,G. Smart,E. Tilling,P. Wilkins,Paul V Beirne,J. Dutchak,Ian Needleman,G. Okem,C. Sharpin,L. Thomas,D. Wonderling,P. Robb,J. Struthers,P. Duncan,A Williams +29 more
TL;DR: In this article, the authors present a systematic review of clinical oral examinations in detecting oral cancer and potentially malignant conditions, and the authors propose a guideline for routine dental check-ups.
Journal ArticleDOI
The subclass of IgG antibody in allergic disease: II. The IgG subclass of antibodies produced following natural exposure to dust mite and grass pollen in atopic and non-atopic individuals.
TL;DR: Data show that all subjects were capable of recognizing and mounting an IgG1 antibody response to these inhaled antigens, and that atopic individuals differed from normal subjects in the frequency with which they made IgG4 antibodies in response to natural exposure to both dust mites and pollen.