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David F. Richards
Researcher at King's College London
Publications - 50
Citations - 4619
David F. Richards is an academic researcher from King's College London. The author has contributed to research in topics: Cytokine & Interleukin 10. The author has an hindex of 28, co-authored 50 publications receiving 4386 citations. Previous affiliations of David F. Richards include Guy's Hospital & University of Cambridge.
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Journal ArticleDOI
Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10
Sarah Dimeloe,Louise V. Rice,Hebe Chen,Charlotte E. Cheadle,John G. Raynes,Paul E Pfeffer,Paul Lavender,David F. Richards,Mun Peak Nyon,James M. McDonnell,Claudia Kemper,Bibek Gooptu,Catherine M. Hawrylowicz +12 more
TL;DR: Human CD4+ T cells exposed to 1,25(OH)2D3 secrete α-1-antitrypsin – representing a novel cellular source of this protein, which promotes IL-10 secretion by human CD4- T cells, via direct interaction with complement C3a.
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T cells producing the anti-inflammatory cytokine IL-10 regulate allergen-specific Th2 responses in human airways.
Alexander Faith,Narinder Singh,Narinder Singh,S. Farooque,Sarah Dimeloe,David F. Richards,Hui Lu,D Roberts,Elfy B Chevretton,Tak H. Lee,Christopher Corrigan,Catherine M. Hawrylowicz +11 more
TL;DR: This study aimed to investigate whether local IL‐10 production regulates responses by respiratory mucosal leucocytes isolated from nasal polyps.
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1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3- T cells.
TL;DR: It is shown that 1,25(OH)2D3 enhances expression of CD73 on CD4+ Foxp3– T cells in a process that is at least partially TGF‐β‐dependent, revealing an additional contributing mechanism by which vitamin D may be protective in immune‐mediated disease.
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Vitamin D binding protein and asthma severity in children
Atul Gupta,Sarah Dimeloe,David F. Richards,Andrew Bush,Sejal Saglani,Catherine M. Hawrylowicz +5 more
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The use of monoclonal and polyspecific antibodies in the IgE sandwich ELISA
TL;DR: The sandwich ELISA using polyspecific rabbit antibody was substantially moresensitive than conventional ELISA and also marginally more sensitive than RAST and showed good agreement with the radioallergosorbent test.