D
David G. Cook
Researcher at University of Nottingham
Publications - 140
Citations - 6072
David G. Cook is an academic researcher from University of Nottingham. The author has contributed to research in topics: Traumatic brain injury & Cardiopulmonary bypass. The author has an hindex of 35, co-authored 133 publications receiving 5165 citations. Previous affiliations of David G. Cook include University of Wisconsin-Madison & Loughborough University.
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Journal ArticleDOI
Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone: A Preliminary Study
G. Stennis Watson,Brenna Cholerton,Mark A. Reger,Laura D. Baker,Stephen R. Plymate,Stephen R. Plymate,Sanjay Asthana,Mark A. Fishel,J. Jacob Kulstad,Pattie S. Green,David G. Cook,David G. Cook,David G. Cook,Steven E. Kahn,Steven E. Kahn,Michelle L. Keeling,B. S. Suzanne Craft +16 more
TL;DR: Preliminary support is provided that rosiglitazone may offer a novel strategy for the treatment of cognitive decline associated with AD, consistent with recent reports that plasma Aβ42 decreases with progression of AD.
Journal ArticleDOI
Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit
William A. Banks,Alicia M. Gray,Michelle A. Erickson,Therese S. Salameh,Mamatha Damodarasamy,Nader Sheibani,James S. Meabon,Emily E. Wing,Yoichi Morofuji,Yoichi Morofuji,David G. Cook,May J. Reed +11 more
TL;DR: The BBB is relatively resistant to LPS-induced disruption with some brain regions more vulnerable than others and based on in vivo and in vitro measures of neuroinflammation, it appears that astrocytes, microglia/macrophages, and pericytes play little role in the L PS-mediated disruption of the BBB.
Journal ArticleDOI
Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone
G. Stennis Watson,Brenna Cholerton,Mark A. Reger,Laura D. Baker,Stephen R. Plymate,Stephen R. Plymate,Sanjay Asthana,Mark A. Fishel,J. Jacob Kulstad,Pattie S. Green,David G. Cook,David G. Cook,David G. Cook,Steven E. Kahn,Steven E. Kahn,Michelle L. Keeling,Suzanne Craft +16 more
TL;DR: Preliminary support is provided that rosiglitazone may offer a novel strategy for the treatment of cognitive decline associated with AD, consistent with recent reports that plasma Abeta42 decreases with progression of AD.
Journal ArticleDOI
Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele
David G. Cook,David G. Cook,James B. Leverenz,James B. Leverenz,Pamela J. McMillan,Pamela J. McMillan,J. Jacob Kulstad,J. Jacob Kulstad,Sasha Ericksen,Richard A. Roth,Gerard D. Schellenberg,Lee-Way Jin,Kristina S. Kovacina,Suzanne Craft +13 more
TL;DR: Findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Abeta metabolism.
Journal ArticleDOI
Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms
Elaine R. Peskind,Elaine R. Peskind,Eric C. Petrie,Eric C. Petrie,Donna J. Cross,Kathleen F. Pagulayan,Kathleen F. Pagulayan,Kathleen McCraw,David Hoff,Kim Hart,Chang En Yu,Chang En Yu,Murray A. Raskind,Murray A. Raskind,David G. Cook,David G. Cook,Satoshi Minoshima +16 more
TL;DR: Brain fluorodeoxyglucose positron emission tomography findings suggest that regional brain hypometabolism may constitute a neurobiological substrate for chronic PCS in Iraq combat Veterans with repetitive blast-trauma mTBI.