M
Mark A. Fishel
Researcher at University of Washington
Publications - 29
Citations - 4328
Mark A. Fishel is an academic researcher from University of Washington. The author has contributed to research in topics: Computer science & Insulin. The author has an hindex of 10, co-authored 11 publications receiving 3941 citations. Previous affiliations of Mark A. Fishel include United States Department of the Army & Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Effects of aerobic exercise on mild cognitive impairment: a controlled trial.
Laura D. Baker,Laura L. Frank,Karen E. Foster-Schubert,Pattie S. Green,Charles W. Wilkinson,Anne McTiernan,Stephen R. Plymate,Mark A. Fishel,G. Stennis Watson,Brenna Cholerton,Glen E. Duncan,Pankaj D. Mehta,Suzanne Craft +12 more
TL;DR: Six months of high-intensity aerobic exercise had sex-specific effects on cognition, glucose metabolism, and hypothalamic-pituitary-adrenal axis and trophic activity despite comparable gains in cardiorespiratory fitness and body fat reduction.
Journal ArticleDOI
Intranasal insulin improves cognition and modulates β-amyloid in early AD
Mark A. Reger,G. S. Watson,Pattie S. Green,Charles W. Wilkinson,Laura D. Baker,Brenna Cholerton,Mark A. Fishel,S. R. Plymate,John C.S. Breitner,William DeGroodt,P. Mehta,P. Mehta,Suzanne Craft +12 more
TL;DR: The results of this pilot study support further investigation of the benefits of intranasal insulin for patients with Alzheimer disease, and suggest that intran asal peptide administration may be a novel approach to the treatment of neurodegenerative disorders.
Journal ArticleDOI
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype.
Mark A. Reger,Mark A. Reger,G.S. Watson,G.S. Watson,William H. Frey,William H. Frey,Laura D. Baker,Laura D. Baker,Brenna Cholerton,Brenna Cholerton,M.L. Keeling,M.L. Keeling,Dana Belongia,Dana Belongia,Mark A. Fishel,Mark A. Fishel,S. R. Plymate,S. R. Plymate,Gerard D. Schellenberg,Monique M. Cherrier,Monique M. Cherrier,Suzanne Craft,Suzanne Craft +22 more
TL;DR: It is suggested that intranasal insulin administration may have therapeutic benefit without the risk of peripheral hypoglycemia and further evidence for apolipoprotein E (APOE) related differences in insulin metabolism is provided.
Journal ArticleDOI
Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone: A Preliminary Study
G. Stennis Watson,Brenna Cholerton,Mark A. Reger,Laura D. Baker,Stephen R. Plymate,Stephen R. Plymate,Sanjay Asthana,Mark A. Fishel,J. Jacob Kulstad,Pattie S. Green,David G. Cook,David G. Cook,David G. Cook,Steven E. Kahn,Steven E. Kahn,Michelle L. Keeling,B. S. Suzanne Craft +16 more
TL;DR: Preliminary support is provided that rosiglitazone may offer a novel strategy for the treatment of cognitive decline associated with AD, consistent with recent reports that plasma Aβ42 decreases with progression of AD.
Journal ArticleDOI
Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults
Mark A. Reger,Mark A. Reger,G. Stennis Watson,G. Stennis Watson,Pattie S. Green,Pattie S. Green,Laura D. Baker,Laura D. Baker,Brenna Cholerton,Brenna Cholerton,Mark A. Fishel,Mark A. Fishel,Stephen R. Plymate,Stephen R. Plymate,Monique M. Cherrier,Gerard D. Schellenberg,William H. Frey,Suzanne Craft,Suzanne Craft +18 more
TL;DR: The findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration, and whether the effects of insulin differ between participants with and without the APOE- epsilon4 allele.