David Grundmann

TL;DR: This study confirms the recently reported association between PD and the abundance of certain gut microbiota and shows a reduction in fecal SCFA concentrations, which might, theoretically, induce alterations in the ENS and contribute to gastrointestinal dysmotility in PD.

TL;DR: The data indicate that calprotectin, alpha-1-antitrypsin and zonulin could be useful non-invasive markers in PD as well, and corroborate the hypothesis of an intestinal inflammation as contributing factor in the pathogenesis of PD.

TL;DR: The EGC population is species specific and as complex as CNS glia, and heterogeneity in morphology, localization, and transcription as well as interaction with surrounding cells indicate versatile functional properties of these cells for gut function in health and disease.

TL;DR: The isolation of pure MP in large amounts allows new analytical approaches that can provide a new perspective in evaluating changes of the ENS in experimental models, human disease and aging.

TL;DR: Impacts of HSCR-smooth-muscle-protein extracts upon isolated myenteric plexus cells, dissociated dorsal root ganglia and NCSC were studied in vitro to investigate the quality of this microenvironment effects.