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David J. Gladstone
Researcher at Dartmouth–Hitchcock Medical Center
Publications - 156
Citations - 3777
David J. Gladstone is an academic researcher from Dartmouth–Hitchcock Medical Center. The author has contributed to research in topics: Cherenkov radiation & Dosimetry. The author has an hindex of 33, co-authored 156 publications receiving 3106 citations. Previous affiliations of David J. Gladstone include Dartmouth College & Harvard University.
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Journal ArticleDOI
Analysis of prostate and seminal vesicle motion : implications for treatment planning
Clair J. Beard,Peter K. Kijewski,Marc R. Bussière,Rebecca Gelman,David J. Gladstone,Kitt Shaffer,Marianne Plunkett,Philip Costello,C. Norman Coleman +8 more
TL;DR: Although the target position at the time of planning CT may differ substantially from the mean treatment position, target motion cannot be predicted by evaluating simply measured parameters from a single scan, or double scan sequence.
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Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose.
TL;DR: For x-ray photons the light emission would be optimally suited for narrow beam stereotactic radiation therapy and surgery validation studies, for verification of dynamic intensity-modulated and volumetric modulated arc therapy treatment plans in water tanks, near monoenergetic sources and also for entrance and exit surface imaging dosimetry of both narrow and broad beams.
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A numerical simulation of organ motion and daily setup uncertainties: Implications for radiation therapy
TL;DR: In this article, a Monte Carlo approach was used to simulate the cumulative effect of variation in overall tumor position, for individual treatment fractions, relative to a fixed distribution of dose, in the presence of organ motion and physical setup error.
Journal ArticleDOI
Cerenkov emission induced by external beam radiation stimulates molecular fluorescence
TL;DR: The results here indicate that molecular fluorescence monitoring during external beam radiotherapy is possible and also demonstrates that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms.
Journal ArticleDOI
Projection imaging of photon beams by the Čerenkov effect.
Adam K. Glaser,Scott C. Davis,David M. McClatchy,Rongxiao Zhang,Brian W. Pogue,David J. Gladstone +5 more
TL;DR: This initial study demonstrates the first documented use of Čerenkov emission imaging to profile x-ray photon LINAC beams in water and has several potential advantages over alternative methods, and upon future refinement may prove to be a robust and novel dosimetry method.