D
David J. Gracie
Researcher at University of Leeds
Publications - 80
Citations - 2152
David J. Gracie is an academic researcher from University of Leeds. The author has contributed to research in topics: Inflammatory bowel disease & Irritable bowel syndrome. The author has an hindex of 18, co-authored 71 publications receiving 1451 citations. Previous affiliations of David J. Gracie include St James's University Hospital & Leeds Teaching Hospitals NHS Trust.
Papers
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Journal ArticleDOI
Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease
Y. Derwa,Y. Derwa,David J. Gracie,David J. Gracie,PJ Hamlin,Alexander C. Ford,Alexander C. Ford +6 more
TL;DR: Ulcerative colitis and Crohn's disease are inflammatory bowel diseases (IBD) and evidence implicates disturbances of the gastrointestinal microbiota in their pathogenesis.
Journal ArticleDOI
Bi-directionality of Brain–Gut Interactions in Patients With Inflammatory Bowel Disease
David J. Gracie,David J. Gracie,Elspeth Guthrie,P John Hamlin,P John Hamlin,Alexander C. Ford,Alexander C. Ford +6 more
TL;DR: Evidence is found for bi-directional effects of IBD activity and psychological disorders in patients with CD or UC from a 2-year longitudinal prospective study of patients in secondary to care.
Journal ArticleDOI
Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis
David J. Gracie,David J. Gracie,Andrew J Irvine,Ruchit Sood,Ruchit Sood,Antonina Mikocka-Walus,Antonina Mikocka-Walus,P John Hamlin,Alexander C. Ford,Alexander C. Ford +9 more
TL;DR: A systematic review and meta-analysis of Randomised controlled trials recruiting patients with inflammatory bowel disease aged at least 16 years that compared psychological therapy with a control intervention or usual treatment found no effect on disease activity indices or other psychological wellbeing scores when compared with control.
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The influence of the brain-gut axis in inflammatory bowel disease and possible implications for treatment.
TL;DR: Observational data suggest that the effect of disordered brain-gut axis activity in IBD is substantial, and scope remains for further well designed trials of psychological therapies and antidepressants, particularly in the subset of patients who have coexistent psychological disorders, or in those who report IBS-type symptoms.
Journal ArticleDOI
Systematic review with meta-analysis: the adverse effects of tobacco smoking on the natural history of Crohn's disease.
TL;DR: Tobacco smoking is a well‐established risk factor for the development of Crohn's disease, and this may lead to a more complicated disease course, but recent evidence suggests that many patients with Crohn' s disease are unaware of this fact.