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Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis

David J. Gracie, +9 more
- 01 Mar 2017 - 
- Vol. 2, Iss: 3, pp 189-199
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TLDR
A systematic review and meta-analysis of Randomised controlled trials recruiting patients with inflammatory bowel disease aged at least 16 years that compared psychological therapy with a control intervention or usual treatment found no effect on disease activity indices or other psychological wellbeing scores when compared with control.
About: 
This article is published in The Lancet Gastroenterology & Hepatology.The article was published on 2017-03-01 and is currently open access. It has received 204 citations till now. The article focuses on the topics: Comorbidity & Inflammatory bowel disease.

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Bi-directionality of Brain–Gut Interactions in Patients With Inflammatory Bowel Disease

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TL;DR: Observational data suggest that the effect of disordered brain-gut axis activity in IBD is substantial, and scope remains for further well designed trials of psychological therapies and antidepressants, particularly in the subset of patients who have coexistent psychological disorders, or in those who report IBS-type symptoms.
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References
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Measuring inconsistency in meta-analyses

Julian P T Higgins, +3 more
- 04 Sep 2003 - 
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

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TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.

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Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials

Jonathan A C Sterne, +18 more
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TL;DR: How to interpret funnel plot asymmetry, recommends appropriate tests, and explains the implications for choice of meta-analysis model are described.
Related Papers (5)

Controversies Revisited : A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases.

Antonina Mikocka-Walus, +4 more
- 01 Mar 2016 - 

Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease

Antonina Mikocka-Walus, +164 more
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Depression and anxiety in patients with Inflammatory Bowel Disease: A systematic review

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The Hospital Anxiety and Depression Scale.

A. S. Zigmond, +1 more
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The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders.

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Frequently Asked Questions (5)
Q1. What contributions have the authors mentioned in the paper "This is a repository copy of effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review" ?

This is indicated by the licence information on the White Rose Research Online record for the item. 

Methods: MEDLINE, EMBASE, EMBASE Classic, PsychINFO and the Cochrane central register of controlled trials were searched through September 2016. 

Randomised controlled trials (RCTs) recruiting patients ≥16 years with IBD that compared psychological therapy with a control intervention or treatment as usual were eligible. 

Telephone: +441132684963 Facsimile: +441132429722Keywords: inflammatory bowel diseasemood cognitive behaviour therapy psychological therapyWord count: 4,576Background: Inflammatory bowel disease (IBD) may be associated with psychological comorbidity and impaired quality of life. 

Interpretation: Psychological therapies, and CBT in particular, may have limited short-term beneficial effects on depression scores and quality of life in patients with IBD.