David J. Loskutoff

TL;DR: The results suggest that elevated MCP-1 may induce adipocyte dedifferentiation and contribute to pathologies associated with hyperinsulinemia and obesity, including type II diabetes.

TL;DR: Analysis of treated and untreated conditioned medium by gel filtration revealed that the latent and active PAIs migrated with apparent Mr values of 30,000 and 50,000, respectively, which indicate that the two PAIs are immunologically related and suggest thatThe latent form is converted into the active form by the sodium dodecyl sulfate present during the purification.

TL;DR: Examination of the expression of PAI-1 mRNA in segments of 11 severely diseased and 5 relatively normal human arteries obtained from 16 different patients undergoing reconstructive surgery for aortic occlusive or aneurysmal disease provides initial evidence for the increased expression and suggests a role for PAi-1 in the progression of human atherosclerotic disease.

TL;DR: The fact that both rIL-1 beta and rTNF alpha act in a similar manner strengthens the hypothesis that the local development of inflammatory/immune processes could reduce endothelial fibrinolytic activity.

TL;DR: A dynamic regulatory role for PAI-1 and uPA in uPAR-mediated cell adhesion and release is suggested, and may help to explain why high PAi-1 levels indicate a poor prognosis for many cancers.