D
David K. Blough
Researcher at University of Washington
Publications - 112
Citations - 10711
David K. Blough is an academic researcher from University of Washington. The author has contributed to research in topics: Population & Cancer. The author has an hindex of 48, co-authored 112 publications receiving 9725 citations. Previous affiliations of David K. Blough include Duke University & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
Helen E. Smith,Jeffrey P. Jones,Thomas F. Kalhorn,Federico M. Farin,Patricia L. Stapleton,Connie L. Davis,James D. Perkins,David K. Blough,Mary F. Hebert,Kenneth E. Thummel,Rheem A. Totah +10 more
TL;DR: Inheritance of CYP2C8*3 is associated with a higher risk of developing renal toxicity in patients treated chronically with CNIs, and especially Tac, possibly by reducing formation of kidney protecting vasodilatory epoxyeicosatrienoic acids.
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Effect of radiotherapy interruptions on survival in medicare enrollees with local and regional head-and-neck cancer
Megan D. Fesinmeyer,Vivek K. Mehta,David K. Blough,David K. Blough,Lauri Tock,Scott D. Ramsey,Scott D. Ramsey +6 more
TL;DR: Treatment interruptions seem to influence survival time among patients with laryngeal tumors completing a full course of radiotherapy, and at all head-and-neck sites, the association between interruptions and survival is sensitive to confounding by stage and other treatments.
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Characterization of prescribing errors in an internal medicine clinic.
Emily Beth Devine,Jennifer L. Wilson-Norton,Nathan M. Lawless,Ryan N. Hansen,Thomas K. Hazlet,Kerry Kelly,William Hollingworth,David K. Blough,Sean D. Sullivan +8 more
TL;DR: A pilot study was conducted to characterize the epidemiology of prescribing errors, comparing those that occurred pre- to postimplementation of an electronic prescribing system and the results of the study during the preimplementation phase, when a handwritten prescription process was still in place.
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Benzodiazepine use and physical performance in community-dwelling older women.
Shelly L. Gray,Brenda W.J.H. Penninx,David K. Blough,Margaret B. Artz,Jack M. Guralnik,Robert B. Wallace,David M. Buchner,Andrea Z. LaCroix +7 more
TL;DR: To determine whether benzodiazepine use in older women increased the risk of decline in physical function, a large sample of women aged 60 and over was surveyed.
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Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation.
Jeannine S. McCune,Linda J. Risler,Brian Phillips,Kenneth E. Thummel,David K. Blough,Danny D. Shen +5 more
TL;DR: CYP3A5*1 genotype is associated with higher rates of ifosfamide N-dechloroethylation in human liver and kidneys, and is significantly associated with CYP3A4 and CYP 3A5 protein concentration but not with age, sex, or CYP2B6 protein concentration.