D
David M. Haig
Researcher at University of Nottingham
Publications - 79
Citations - 2644
David M. Haig is an academic researcher from University of Nottingham. The author has contributed to research in topics: Virus & Gene. The author has an hindex of 32, co-authored 79 publications receiving 2490 citations.
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Journal ArticleDOI
Malignant catarrhal fever: a review.
TL;DR: The pathogenesis of MCF and the virus life cycle are poorly understood and, currently, there is no effective disease control, but new and improved methods of disease diagnosis have been developed and promising vaccine strategies are being tested.
Journal Article
Ovine diseases. Orf.
David M. Haig,Andrew A. Mercer +1 more
TL;DR: Several virus putative virulence genes have been identified, including viral homologues of ovine vascular endothelial growth factor (VEGF); ovine IL-10; vaccinia virus E3L interferon resistance gene; and in addition a viral activity that inhibits the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF).
Journal ArticleDOI
Orf Virus Encodes a Novel Secreted Protein Inhibitor of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2
David Deane,Colin McInnes,Ann Percival,Ann R. Wood,Jackie Thomson,Andrea Lear,Janice Gilray,Stephen B. Fleming,Andrew A. Mercer,David M. Haig +9 more
TL;DR: GIF expression by orf virus indicates that GM-CSF and IL-2 are important in host antiviral immunity.
Journal ArticleDOI
Immunity and counter-immunity during infection with the parapoxvirus orf virus
David M. Haig,Colin McInnes +1 more
TL;DR: The study of the immuno-modulator proteins provides an insight into disease pathogenesis and important elements of a host protective response and this information will be used to devise a rational disease control strategy.
Journal ArticleDOI
The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferon‐inducible, double‐stranded RNA‐dependent kinase
TL;DR: Results indicate that the OVIFNR gene functions as an interferon‐resistance gene, the product of which inhibits PKR in a similar way to the vaccinia virus E3L gene product.