Showing papers by "David M. Jacobowitz published in 1977"
TL;DR: Surgical transections at the level of mesencephalic-pontine junction caused no significant changes in 5-HT concentrations or tryptophan hydroxylase levels in the hypothalamus, limbic system, cerebral cortex or spinal cord.
167 citations
TL;DR: In prolonged isolation, it appears that the reduction of external stimuli results in a decrease in catecholaminergic activity in some limbic areas which may correlate with increased levels of emotionality and aggression.
77 citations
TL;DR: The present work will focus on the gamma-aminobutyric acid (GABA) system in the Hb, as manifested by the activity of its synthesizing enzyme glutamic acid decarboxylase (GAD), a marker of GABAergic neurons.
53 citations
TL;DR: The present study examines the effects of prepartal stress on CA concentrations in 23 discrete brain areas associated with norepinephrine (NE)or dopamine-containing pathways in the brain 1,5,14,17,19,2~,2s,a° with a sensitive radioisotopic enzymatic assay for NE and DA.
40 citations
TL;DR: Examination of the ganglia by histofluorescence indicates that NGF increases the bundles of fibres while dexamethasone increases the number of small intensely fluorescent cells, suggesting that dexamETHasone decreases the rate of PNMT destruction.
Abstract: — Nerve-growth factor (NGF) or dexamethasone administered to newborn rats result in increased levels of phenylethanolamine-N-methyl transferase (PNMT) activity in the superior cervical ganglia. Treatment with dexamethasone, but not NGF, also results in increased levels of epinephrine which parallel the increased PNMT in the ganglia. Dexamethasone slows the decrease in PNMT levels after cessation of NGF treatment, suggesting that dexamethasone decreases the rate of PNMT destruction. Examination of the ganglia by histofluorescence indicates that NGF increases the bundles of fibres while dexamethasone increases the number of small intensely fluorescent cells.
24 citations
TL;DR: Whereas the repeated doses of guanethidine caused degeneration of sympathetic nerves, destruction of adrenergic neurons was not found after prolonged treatment with EMD 21192, and plasma catecholamine concentrations reflected the different sites of action of the drugs in the sympathoadrenal system.
16 citations
TL;DR: All peripheral catecholamine-containing elements which function in a modulatory role are not vital to the survival of the individual but rather serve as "fine tune" adjustment that do not involve the central nervous system.
6 citations
TL;DR: Vibratome sectioning in FC-47 should facilitate study of the distribution of ACh and other labile substances in rat brain.
5 citations