Showing papers in "Journal of Investigative Dermatology in 1977"

TL;DR: The laser Doppler method appear to represent a practical technique for clinical evaluation of cutaneous blood flow in any skin surface, and is compared with the 133xenon clearance technique in measuring cutaneous flow in the forearms of normal volunteers.

TL;DR: Once a remission was induced, there was no difference in its maintenance when patients were treated once a week, once every other week, or once every third week, and each of these schedules was superior to no maintenance treatment.

TL;DR: Combined histochemical and biochemical studies confirm earlier reports demonstrating a shift from polar to neutral lipid during cornification and suggest that granular layer polar lipid, through as yet undefined mechanisms, may be transformed into the neutral lipids of the cornified layer.

TL;DR: In man and baboons, the reflex modification in skin blood flow with each degree (C°) change in central temperature is about 20 times greater than that produced by changing skin temperature, however, in baboons and probably other species, the skin vasomotor system appears to be mainly adrenergic.

TL;DR: The morphology of psoriatic capillary loops changed from venous capillary to arterial capillaries which are found in the papillae of normal skin following 3 weeks of Goeckerman therapy.

TL;DR: It is concluded that the information currently available about the thermal properties of skin and their normal variation with body site, skin color, and age is quite limited.

TL;DR: The findings suggest that the normal connective tissue elements may have been stimulated to produce an increased amount of collagenase and emphasize the importance of epithelial-stromal interaction in soft tissue invasiveness.

TL;DR: The ultrastructural features of the capillary loops and those of the microcirculatory segments in the horizontal dermal plexus should provide sufficient criteria for one to evaluate the nature of vascular abnormalities that occur in the upper dermis.

TL;DR: The cutaneous mechanoreceptors of the cat can be assigned to one of 11 groups by using physiologic tests performed with hand-held stimulators, and the validity and utility of this classification scheme are discussed.

TL;DR: The Merkel cell, a neural crest migrant to the skin, possesses a characteristic intranuclear rodlet, cytoplasmic membrane-bound granules, and horn projections and is usually associated with nerve terminations.

TL;DR: The viscoelastic data suggest that the outermost layers of the stratum corneum may become dry in vivo despite their proximity to the underlying wet tissue, and that the instrument is sensitive enough to measure the changes that occur.

TL;DR: The demonstration of markedly increased levels of collagenase in normal-appearing skin could, in part, provide an explanation at the molecular level for the formation of blisters in this disease.

TL;DR: To gain a more fundamental understanding of the frictional properties of skin, various parameters (hydration, oils, surfactants, etc) affecting skin friction were evaluated using a rotational friction technique.

TL;DR: The structure of mouse tail epidermis has been investigated from day 15 of embryonic development and a qualitative and quantitative analysis of the localization of Langerhans cells has been carried out using the ATPase method.

TL;DR: Psychophysical observations and physiologic records indicate that the temporal suppression of heat-induced first pain is related to the suppression of A heat nociceptors and that prolonged temporal summation of second pain isrelated to summation within the central nervous system.

TL;DR: Alteration of the skin induced by single and repeated long-wave ultraviolet (UVA) exposures was studied and the formation of cross-banded filamentous aggregations was observed in the superficial and reticular dermis.

TL;DR: Tests performed on the upper backs of 23 healthy adult males were used to investigate the variations in the material constants with age and sun-exposure habits, and variations with sun exposure habits were related to known dermal collagen and elastin changes due to ultraviolet radiation.

TL;DR: The kinetics of the appearance of immunoreactants and cells implies that immunoglobulin and probably circulating immune complexes are present prior to the development of inflammation and supports the contention that deposition of immune complexes within vessel walls is responsible for leukocytoclastic vasculitis.

TL;DR: The sweat glands of human beings and macaques are innervated with large numbers of cholinergic terminals and a few adrenergic terminals, and after macaque ulnar nerves were constricted, fluorescent catecholamines were demonstrated in the proximal sides of the axons.

TL;DR: The ventral side of the earlobes of Syrian hamsters richly endowed with sebaceous glands are measured by planimetry, cellular activity by autoradiography, and cellular activity using tritiated thymidine and tritated histidine to determine gland size and labeling index.

TL;DR: The use of impedance measurement with closely spaced electrodes gives an indication of the hydration of the superficial horny layer and also demonstrates reabsorption of sweat from this region.

TL;DR: A linear, continuous basement membrane zone pattern was noted in 83% of oral mucosal biopsy specimens studied, and Circulating antibasement membrane zone antibodies were noted in the sera of two patients with cicatricial pemphigoid.

TL;DR: It has been possible to induce ovalbumin mRNA synthesis in vitro by combining purified steroid hormone-receptor complexes with RNA polymerase interphase chromosomes and necessary substrates and it is suggested that steroid hormone receptors act directly on the cells genetic apparatus to promote gene expression.

TL;DR: The salient features of recurrent aphthous stomatitis suggest that it is a heterogeneous entity and a possible immunopathogenesis and the evidence for this is reviewed.

TL;DR: The results presented indicate that not all proteins in the skin are capable of being the carrier protein in photoallergy of TCSA- and that cross reactivity to other halogenated salicylanilides can be explained by further photochemical reactions ofTCSA- photoproducts.

TL;DR: Two in vivo techniques which are rapid, inexpensive, and reproducible, and capable of detecting small degrees of dermal atrophy after the application of topical corticosteroid preparations for only one month have been investigated.

TL;DR: A general model of the autonomic neuroeffector junction is proposed, with emphasis on the muscle effector bundle with electrotonic coupling between individual cells via gap junctions and en passage release of transmitter from autonomic nerve varicosities.

TL;DR: In the newborn rat, innervated Merkel cells were observed in the epidermis of the back and belly next to the tylotrich follicles and from 0 to 13 days after birth, the nerve endings on the Merkel cells and transitional cells were filled with clear-cored, synaptic-sized vesicles.