D
David R Thickett
Researcher at University of Birmingham
Publications - 249
Citations - 7200
David R Thickett is an academic researcher from University of Birmingham. The author has contributed to research in topics: ARDS & Lung injury. The author has an hindex of 42, co-authored 224 publications receiving 5789 citations. Previous affiliations of David R Thickett include Queen Elizabeth Hospital Birmingham & Heart of England NHS Foundation Trust.
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Journal ArticleDOI
The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial.
TL;DR: Experimental data suggest that manipulation ofAlveolar fluid clearance with β-agonists can accelerate the resolution of alveolar edema and improve survival in adult patients with acute lung injury or acute respiratory distress syndrome.
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Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
Rachel Dancer,Dhruv Parekh,Sian Lax,Vijay K. D'Souza,Shengxing Zheng,Chris Bassford,Daniel Park,Domokos Bartis,Rahul Y Mahida,Alice M Turner,Elizabeth Sapey,Wenbin Wei,Babu Naidu,Paul M. Stewart,William D. Fraser,Kenneth B. Christopher,Mark S. Cooper,Fang Gao,David M. Sansom,Adrian R. Martineau,Gavin D. Perkins,David R Thickett +21 more
TL;DR: Vitamin D deficiency is common in people who develop ARDS and appears to contribute to the development of the condition, and approaches to correct vitamin D deficiency in patients at risk of ARDS should be developed.
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Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers
Murali Shyamsundar,Scott McKeown,Cecilia O'Kane,Thelma R. Craig,Vanessa Brown,David R Thickett,Michael A. Matthay,Clifford C. Taggart,Janne T. Backman,J. Stuart Elborn,Daniel F. McAuley +10 more
TL;DR: Simvastatin has antiinflammatory effects in the pulmonary and systemic compartment in humans exposed to inhaled LPS.
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Epithelial–mesenchymal transition in lung development and disease: does it exist and is it important?
TL;DR: A brief insight is given into the mechanism and assessment methods of EMT in various pulmonary diseases and the recent literature highlighting the controversial experimental data and conclusions is summarized.
Journal ArticleDOI
Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome.
TL;DR: It is concluded that VEGF makes a significant contribution to the endothelial cell permeability-inducing activity in plasma from patients with ARDS, and may play an important role in the development of noncardiogenic pulmonary edema in ARDS.