D
David Spanswick
Researcher at University of Warwick
Publications - 83
Citations - 4145
David Spanswick is an academic researcher from University of Warwick. The author has contributed to research in topics: Hyperpolarization (biology) & Patch clamp. The author has an hindex of 27, co-authored 80 publications receiving 3820 citations. Previous affiliations of David Spanswick include Coventry Health Care & University of Aberdeen.
Papers
More filters
Journal ArticleDOI
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
TL;DR: It is shown that leptin hyperpolarizes glucose-receptive hypothalamic neurons of lean Sprague–Dawley and Zucker rats, but is ineffective on neurons of obese Zucker (fa/fa ) rats, and single-channel recordings demonstrate that leptin activates an ATP-sensitive potassium (KATP) channel.
Journal ArticleDOI
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats.
David Spanswick,Mark A. Smith,S. Mirshamsi,Vanessa H. Routh,Vanessa H. Routh,Michael L.J. Ashford +5 more
TL;DR: It is demonstrated that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive neurons by opening KATP channels, which suggest hypothalamic KatP channel function is crucial to physiological regulation of food intake and body weight.
Journal ArticleDOI
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus.
TL;DR: Rat ARC neurons containing neuropeptide Y and agouti-related protein, which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin to propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.
Journal ArticleDOI
Leptin Mediates the Increase in Blood Pressure Associated with Obesity
Stephanie E. Simonds,Jack T. Pryor,Eric Ravussin,Frank L. Greenway,Ralph J. DiLeone,Andrew M. Allen,Jaspreet K. Bassi,Joel K. Elmquist,Julia M. Keogh,Elana Henning,Martin G. Myers,Julio Licinio,Russell D. Brown,Pablo J. Enriori,Stephen O'Rahilly,Scott M. Sternson,Kevin L. Grove,David Spanswick,David Spanswick,I. Sadaf Farooqi,Michael A. Cowley +20 more
TL;DR: It is demonstrated that leptin couples changes in weight to changes in BP in mammalian species, and humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity.
Journal ArticleDOI
The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish.
Vance L. Trudeau,David Spanswick,E.J. Fraser,K. Larivière,D. Crump,S. Chiu,M MacMillan,Rüdiger W. Schulz +7 more
TL;DR: A working model for the involvement of glutamate and GABA in the regulation of LH release in teleost fish is proposed and it is suggested that it is a receptor similar to the GABA(A) type which mediates the effects of GABA on LHRelease in fish, at least partially acting on the GnRH neuron, but likely directly acting at the gonadotroph as well.