D
David T. Paik
Researcher at Stanford University
Publications - 41
Citations - 1896
David T. Paik is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Induced pluripotent stem cell. The author has an hindex of 17, co-authored 33 publications receiving 922 citations. Previous affiliations of David T. Paik include Vanderbilt University Medical Center & Cardiovascular Institute of the South.
Papers
More filters
Journal ArticleDOI
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
Robert C. Wirka,Robert C. Wirka,Dhananjay Wagh,David T. Paik,David T. Paik,Milos Pjanic,Milos Pjanic,Trieu Nguyen,Trieu Nguyen,Clint L. Miller,Ramen Kundu,Ramen Kundu,Manabu Nagao,Manabu Nagao,John A. Coller,Tiffany K Koyano,Robyn Fong,Y. Joseph Woo,Boxiang Liu,Stephen B. Montgomery,Joseph C. Wu,Joseph C. Wu,Kuixi Zhu,Rui Chang,Melissa Alamprese,Michelle D. Tallquist,Juyong Brian Kim,Juyong Brian Kim,Thomas Quertermous,Thomas Quertermous +29 more
TL;DR: A protective role for both TCF21 and SMC phenotypic modulation in this disease is established and these cells transform into unique fibroblast-like cells, termed ‘fibromyocytes’, rather than into a classical macrophage phenotype.
Journal ArticleDOI
Single-cell RNA sequencing in cardiovascular development, disease and medicine.
David T. Paik,David T. Paik,Sangkyun Cho,Sangkyun Cho,Lei Tian,Lei Tian,Howard Y. Chang,Joseph C. Wu,Joseph C. Wu +8 more
TL;DR: The currently available scRNA-seq technologies and analytical tools are summarized and the latest findings using sc RNA-seq that have substantially improved knowledge on the development of the cardiovascular system and the mechanisms underlying cardiovascular diseases are discussed.
Journal ArticleDOI
Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells
David T. Paik,David T. Paik,Lei Tian,Lei Tian,Ian M. Williams,Siyeon Rhee,Hao Zhang,Hao Zhang,Chun Liu,Chun Liu,Ridhima Mishra,Sean M. Wu,Sean M. Wu,Kristy Red-Horse,Kristy Red-Horse,Joseph C. Wu,Joseph C. Wu +16 more
TL;DR: This work uses scRNA-seq data generated by the Tabula Muris consortium to uncover transcriptional networks that maintain tissue-specific EC identity and to identify novel angiocrine and functional relationships between tissue- specific ECs.
Journal ArticleDOI
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo
Nigel G. Kooreman,Youngkyun Kim,Patrícia de Almeida,Vittavat Termglinchan,Sebastian Diecke,Sebastian Diecke,Ning-Yi Shao,Tzu-Tang Wei,Hyoju Yi,Devaveena Dey,Raman Nelakanti,Thomas P. Brouwer,David T. Paik,Idit Sagiv-Barfi,Arnold Han,Paul H.A. Quax,Jaap F. Hamming,Ronald Levy,Mark M. Davis,Joseph C. Wu +19 more
TL;DR: Adoptive transfer of T cells isolated from vaccine-treated tumor-bearing mice inhibited tumor growth in unvaccinated recipients, indicating that the iPSC vaccine promotes an antigen-specific anti-tumor T cell response.
Journal ArticleDOI
Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics.
TL;DR: Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery and allow unprecedented opportunities to discover new drug targets and screen compounds for cardiovascular disease.