D
David V. Cohn
Researcher at University of Louisville
Publications - 94
Citations - 4981
David V. Cohn is an academic researcher from University of Louisville. The author has contributed to research in topics: Parathyroid hormone & Chromogranin A. The author has an hindex of 38, co-authored 94 publications receiving 4957 citations. Previous affiliations of David V. Cohn include University of Kansas & University of Missouri–Kansas City.
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Journal ArticleDOI
Biochemical Characterization with Parathormone and Calcitonin of Isolated Bone Cells: Provisional Identification of Osteoclasts and Osteoblasts
TL;DR: Two metabolically distinct types of bone cell populations were isolated from mouse calvaria by a repetitive digestive procedure with a mixture of collagenase and trypsin, and it is postulate that the CT type of populations is enriched in osteoclasts and, possibly, osteocytes, and the PT type of population is enrichment in osteoblasts.
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Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces
Glenda L. Wong,David V. Cohn +1 more
TL;DR: It is established that bone contains at least two types of target cells--one that responds to parathormone but not calcitonin, the other that responds predominantly to calciton in an asymmetric bipolar morphology.
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Separation of parathyroid hormone and calcitonin-sensitive cells from non-responsive bone cells
TL;DR: It has been demonstrated that exposure of mouse calvaria to PTH or CT can lead to an increase in cyclic AMP content and dibutyryl cyclicAMP can by itself induce bone resorption2.
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Selective localization of the parathyroid secretory protein-I/adrenal medulla chromogranin A protein family in a wide variety of endocrine cells of the rat.
TL;DR: The results suggest that this protein family enjoys a widespread but highly restricted distribution in many different endocrine-peptide cells of the rat, many that are believed to be of the APUD cell series.
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1,25-dihydroxycholecalciferol and parathormone: effects on isolated osteoclast-like and osteoblast-like cells.
TL;DR: The data suggest that 1,25-(OH)2D3 and parathormone induce bone resorption by affecting the same cell types (osteoblasts and osteoclasts) although at different cellular sites.