D
David Z. D'Argenio
Researcher at University of Southern California
Publications - 110
Citations - 2654
David Z. D'Argenio is an academic researcher from University of Southern California. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 24, co-authored 105 publications receiving 2465 citations. Previous affiliations of David Z. D'Argenio include City of Hope National Medical Center.
Papers
More filters
Journal ArticleDOI
A program package for simulation and parameter estimation in pharmacokinetic systems.
TL;DR: A set of programs is presented which has been developed for parameter estimation and simulation of models arising from pharmacokinetic applications and has been written for an interactive time-sharing environment with the experimental data and model equations stored in files for future use.
Journal ArticleDOI
Optimal sampling times for pharmacokinetic experiments
TL;DR: It is concluded that optimal sampling and preexperiment simulation may be useful tools for designing informative pharmacokinetic experiments.
Journal ArticleDOI
Bortezomib interactions with chemotherapy agents in acute leukemia in vitro
Terzah M. Horton,Anurhadha Gannavarapu,Susan M. Blaney,David Z. D'Argenio,Sharon E. Plon,Stacey L. Berg +5 more
TL;DR: Bortezomib could potentiate the cytotoxic effects of combination chemotherapy in patients with leukemia, and it is demonstrated that primary leukemia lymphoblasts and leukemia cell lines are sensitive to it.
Journal ArticleDOI
Vitreous VEGF clearance is increased after vitrectomy.
S. S. Lee,Corine Ghosn,Zhiling Yu,Leandro Cabral Zacharias,Henry Kao,Carmine Lanni,Natania Abdelfattah,Baruch D. Kuppermann,Karl G. Csaky,David Z. D'Argenio,James A. Burke,Patrick M. Hughes,Michael R. Robinson +12 more
TL;DR: The back of the eye may be uniquely adapted with rapid-clearance mechanisms to regulate vitreous VEGF levels and partially explain the improvement in macular thickness in some patients with ME.
Journal ArticleDOI
Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine
Julianne L. Holleran,Robert A. Parise,Erin Joseph,Julie L. Eiseman,Joseph M. Covey,Elizabeth R. Glaze,Alexander V. Lyubimov,Ya Fei Chen,David Z. D'Argenio,Merrill J. Egorin +9 more
TL;DR: Zebularine has limited oral bioavailability in mice, rats, and rhesus monkeys, and interspecies scaling projects a CLtb of 296 mL/min in humans.