D
Dawoon Jung
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 8
Citations - 447
Dawoon Jung is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Docking (molecular) & Cell. The author has an hindex of 8, co-authored 8 publications receiving 431 citations. Previous affiliations of Dawoon Jung include St. Jude Children's Research Hospital & Discovery Institute.
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Journal ArticleDOI
Efficient synthetic inhibitors of anthrax lethal factor
Martino Forino,Sherida L. Johnson,Thiang Yian Wong,Dmitri V. Rozanov,Alexei Y. Savinov,Wei Li,Roberto Fattorusso,Barbara Becattini,Andrew Orry,Dawoon Jung,Ruben Abagyan,Jeffrey W. Smith,Ken Alibek,Robert C. Liddington,Alex Y. Strongin,Maurizio Pellecchia +15 more
TL;DR: The data strongly indicate that the scaffold of inhibitors identified is the foundation for the development of novel, safe, and effective emergency therapy of postexposure inhalation anthrax.
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NMR-based techniques in the hit identification and optimisation processes.
Maurizio Pellecchia,Barbara Becattini,Kevin J. Crowell,Roberto Fattorusso,Martino Forino,Marco Fragai,Dawoon Jung,Tomas Mustelin,Lutz Tautz +8 more
TL;DR: In this review, the use of general NMR spectroscopy techniques to detect ligand binding and to monitor enzyme kinetics and inhibition, which appear particularly useful in hit identification and validation, is reiterated.
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Virtual docking approaches to protein kinase B inhibition.
TL;DR: This study led to the identification of low micromolar Akt1 inhibitors, using several strategies including FlexX, GOLD, and CSCORE, where the 100-200 top-scoring compounds from a 50000-compound library were experimentally tested.
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Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies.
Sherida L. Johnson,Dawoon Jung,Martino Forino,Ya Chen,Arnold C. Satterthwait,Dmitry V. Rozanov,and Alex Y. Strongin,Maurizio Pellecchia +7 more
TL;DR: The authors' studies form the basis for the rational design of additional compounds with improved activity and selectivity on newly derived inhibitors of anthrax lethal factor.
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The FRB Domain of mTOR: NMR Solution Structure and Inhibitor Design†,‡
Marilisa Leone,Kevin J. Crowell,Jinhua Chen,Dawoon Jung,Gary G. Chiang,Sina Sareth,Robert T. Abraham,Maurizio Pellecchia +7 more
TL;DR: The NMR solution structure of FRB is reported on and compounds that can directly mimic rapamycin or can dissociate the FRB binding from the inhibition of the catalytic activity of mTOR are identified.