A
Andrew Orry
Researcher at Monash University
Publications - 43
Citations - 2339
Andrew Orry is an academic researcher from Monash University. The author has contributed to research in topics: Docking (molecular) & Allosteric regulation. The author has an hindex of 18, co-authored 39 publications receiving 2171 citations. Previous affiliations of Andrew Orry include Birkbeck, University of London & Norwich Research Park.
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Journal ArticleDOI
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Erin M. Bowers,Gai Yan,Chandrani Mukherjee,Andrew Orry,Ling Wang,Marc A. Holbert,Nicholas T. Crump,Catherine A. Hazzalin,Glen Liszczak,Hua Yuan,Cecilia A. Larocca,S. Adrian Saldanha,Ruben Abagyan,Yan Sun,David J. Meyers,Ronen Marmorstein,Ronen Marmorstein,Louis C. Mahadevan,Rhoda M. Alani,Philip A. Cole +19 more
TL;DR: Inhibition of histone acetylation and cell growth by C646 in cells validate its utility as a pharmacologic probe and suggest that p300/CBP HAT is a worthy anticancer target.
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Isolation and characterisation of microsatellites from hexaploid bread wheat
TL;DR: A high proportion of primer pairs designed to detect simple sequence repeat (SSR) variation in wheat do not generate the expected amplification products and, more significantly, often generate unresolvable PCR products.
Journal ArticleDOI
Ligand docking and structure-based virtual screening in drug discovery.
Claudio N. Cavasotto,Andrew Orry +1 more
TL;DR: A brief tutorial on ligand docking and structure-based virtual screening is presented highlighting current problems and limitations, together with the most recent methodological and algorithmic developments in the field.
Journal ArticleDOI
Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening
Claudio N. Cavasotto,Andrew Orry,Nicholas J. Murgolo,Michael F. Czarniecki,Sue Ann Kocsi,Brian E. Hawes,Kim A. O’Neill,Heather Hine,Marybeth S. Burton,Johannes H. Voigt,Ruben Abagyan,Marvin L. Bayne,Frederick J. Monsma +12 more
TL;DR: The ligand-steered homology modeling method reduces the uncertainty of structure modeling for difficult targets like GPCRs and helps to speed up the development of therapeutics for obesity.
Journal ArticleDOI
Analyses of circular dichroism spectra of membrane proteins.
TL;DR: It was shown that when applied to membrane protein spectra, the resulting calculations produce considerably poorer results, and one source of this discrepancy may be the altered spectral peak positions of membrane proteins due to the different dielectric of the membrane environment relative to that of water.