Cleḿence Queffeĺec,† Marc Petit,†,‡ Pascal Janvier,† D. Andrew Knight, and Bruno Bujoli*,† †LUNAM Universite,́ CNRS, UMR 6230, Chimie Et Interdisciplinarite:́ Synthes̀e Analyse Modeĺisation (CEISAM), UFR Sciences et Techniques, 2, rue de la Houssinier̀e, BP 92208, 44322 NANTES Cedex 3, France ‡Universite ́ Pierre et Marie Curie (UPMC), CNRS, UMR7201, Institut Parisien De Chimie Molećulaire (IPCM), 4 place Jussieu, 75252 Paris Cedex 05, France Chemistry Department, Florida Institute of Technology, 150 West University Boulevard, Melbourne, Florida 32901, United States

Surface modification using phosphonic acids and esters.

Superparamagnetic ferrite nanoparticles (MFe2O4, where M = Fe, Co, Mn) were synthesized through a novel one-step aqueous coprecipitation method based on the use of a new type of alkaline agent: the alkanolamines isopropanolamine and diisopropanolamine. The role played by the bases on the particles’ size, chemical composition, and magnetic properties was investigated and compared directly with the effect of the traditional inorganic base NaOH. The novel MFe2O4 nanomaterials exhibited high colloidal stability, particle sizes in the range of 4–12 nm, and superparamagnetic properties. More remarkably, they presented smaller particle sizes (up to 6 times) and enhanced saturation magnetization (up to 1.3 times) relative to those prepared with NaOH. Furthermore, the nanomaterials exhibited improved magnetic properties when compared with nanoferrites of similar size synthesized by coprecipitation with other bases or by other methods reported in the literature. The alkanolamines were responsible for these achievem...

Superparamagnetic MFe2O4 (M = Fe, Co, Mn) Nanoparticles: Tuning the Particle Size and Magnetic Properties through a Novel One-Step Coprecipitation Route

The ability to non-invasively monitor and treat physiological conditions within the human body has been an aspiration of researchers and medical professionals for decades. The emergences of nanotechnology opened up new possibilities for effective vehicles that could accomplish non-invasive detection of diseases and localized treatment systems to be developed. In turn, extensive research efforts have been spent on the development of imaging moiety that could be used to seek out specific diseased conditions and can be monitored with convention clinical imaging modalities. Nanoscale detection agents like these have the potential to increase early detection of pathophysiological conditions because they have the capability to detect abnormal cells before they even develop into diseased tissue and/or tumors. Once the diseased cells are detected it would be constructive to just be able to treat them simultaneously. From here, the concept of multifunctional carriers that could target, detect, and treat diseased cells emerged. The term “theranostics” has been created to describe this promising area of research that focuses on the combination of diagnostic detection agents with therapeutic drug delivery carriers. Targeted theranostic nanocarriers offer an attractive improvement to disease treatment because of their ability to simultaneously diagnose, image, and treat at targeted diseased sites. Research efforts in the field of theranostics encompass a broad variety of drug delivery vehicles, detection agents, and targeting modalities for the development of an all-in-one, localized, diagnostic and treatment system. Nanotheranostic systems that utilize metallic or magnetic imaging nanoparticles have the added capability to be used as thermal therapeutic systems. This review aims to explore recent advancements in the field of nanotheranostics and the various fundamental components of an effective theranostic carrier.

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Responsive theranostic systems: integration of diagnostic imaging agents and responsive controlled release drug delivery carriers.

Preparation, surface functionalization and application of Fe3O4 magnetic nanoparticles.

Functionalized ceramics for biomedical, biotechnological and environmental applications

A low temperature polyol process, based on glycolaldehyde mediated partial reduction of FeCl(3).6H(2)O at 120 degrees C in the presence of sodium acetate as an alkali source and 2, 2(')-(ethylenedioxy)-bis-(ethylamine) as an electrostatic stabilizer has been used for the gram-scale preparation of biocompatible, water-dispersible, amine functionalized magnetite nanoparticles (MNPs) with an average diameter of 6 +/- 0.75 nm. With a reasonably high magnetization (37.8 e.m.u.) and amine groups on the outer surface of the nanoparticles, we demonstrated the magnetic separation and concentration implications of these ultrasmall particles in immunoassay. MRI studies indicated that these nanoparticles had the desired relaxivity for T(2) contrast enhancement in vivo. In vitro biocompatibility, cell uptake and MR imaging studies established that these nanoparticles were safe in clinical dosages and by virtue of their ultrasmall sizes and positively charged surfaces could be easily internalized by cancer cells. All these positive attributes make these functional nanoparticles a promising platform for further in vitro and in vivo evaluations.

Highly biocompatible and water-dispersible, amine functionalized magnetite nanoparticles, prepared by a low temperature, air-assisted polyol process: a new platform for bio-separation and diagnostics (Retraction of vol 5, pg 2883, 2009)

Ectopic vascularized bone formation by human mesenchymal stem cell microtissues in a biocomposite scaffold B Biointerfaces

CORRIGENDUM: Bio-functionalization of magnetite nanoparticles using an aminophosphonic acid coupling agent: new, ultradispersed, iron-oxide folate nanoconjugates for cancer-specific targeting Bio-functionalization of magnetite nanoparticles using an aminophosphonic acid coupling agent: new, ultradispersed, iron-oxide folate nanoconjugates for cancer-specific targeting

A multifunctional iron oxide based nanoformulation for combined cancer-targeted therapy and multimodal imaging has been meticulously designed and synthesized using a chemoselective ligation approach. Novel superparamagnetic magnetite nanoparticles simultaneously functionalized with amine, carboxyl, and azide groups were fabricated through a sequence of stoichiometrically controllable partial succinylation and Cu (II) catalyzed diazo transfer on the reactive amine termini of 2-aminoethylphosphonate grafted magnetite nanoparticles (MNPs). Functional moieties associated with MNP surface were chemoselectively conjugated with rhodamine B isothiocyanate (RITC), propargyl folate (FA), and paclitaxel (PTX) via tandem nucleophic addition of amine to isothithiocyanates, Cu (I) catalyzed azide--alkyne click chemistry and carbodiimide-promoted esterification. An extensive in vitro study established that the bioactives chemoselectively appended to the magnetite core bequeathed multifunctionality to the nanoparticles without any loss of activity of the functional molecules. Multifunctional nanoparticles, developed in the course of the study, could selectively target and induce apoptosis to folate-receptor (FR) overexpressing cancer cells with enhanced efficacy as compared to the free drug. In addition, the dual optical and magnetic properties of the synthesized nanoparticles aided in the real-time tracking of their intracellular pathways also as apoptotic events through dual fluorescence and MR-based imaging.

Debasish Mishra

Papers

Highly biocompatible and water-dispersible, amine functionalized magnetite nanoparticles, prepared by a low temperature, air-assisted polyol process: a new platform for bio-separation and diagnostics (Retraction of vol 5, pg 2883, 2009)

Ectopic vascularized bone formation by human mesenchymal stem cell microtissues in a biocomposite scaffold B Biointerfaces

``Clickable'', Trifunctional Magnetite Nanoparticles and Their Chemoselective Biofunctionalization (vol 22, pg 1181, 2011)