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Debora Colangelo
Researcher at Sapienza University of Rome
Publications - 18
Citations - 1796
Debora Colangelo is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Kyphosis & Population. The author has an hindex of 8, co-authored 18 publications receiving 1230 citations. Previous affiliations of Debora Colangelo include Scripps Health & University of Minnesota.
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Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
New classification for the treatment of pyogenic spondylodiscitis: validation study on a population of 250 patients with a follow-up of 2 years
Enrico Pola,G Autore,V. M. Formica,V. Pambianco,Debora Colangelo,Roberto Cauda,Massimo Fantoni +6 more
TL;DR: Standardized treatment of PS is highly recommended to ensure patients a good quality of life and helps spine surgeons to significantly reduce complications and costs and to avoid overtreatment.
Journal ArticleDOI
Is posterior percutaneous screw-rod instrumentation a safe and effective alternative approach to TLSO rigid bracing for single-level pyogenic spondylodiscitis? Results of a retrospective cohort analysis
Luigi Aurelio Nasto,Debora Colangelo,Valentina Mazzotta,Eugenia Di Meco,Valentina Neri,Riccardo A. Nasto,Massimo Fantoni,Enrico Pola +7 more
TL;DR: Posterior percutaneous spinal instrumentation is a safe, feasible, and effective procedure in relieving pain, preventing deformity, and neurologic compromise in patients affected by noncomplicated lower thoracic or lumbar PS.
Journal ArticleDOI
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Jing Zhao,Jing Zhao,Jing Zhao,Lei Zhang,Lei Zhang,Aiping Lu,Yingchao Han,Debora Colangelo,Debora Colangelo,Christina Bukata,Alex C. Scibetta,Matthew J. Yousefzadeh,Matthew J. Yousefzadeh,Xuesen Li,Aditi U. Gurkar,Sara J. McGowan,Sara J. McGowan,Luise Angelini,Luise Angelini,Ryan D. O’Kelly,Ryan D. O’Kelly,Hongshuai Li,Lana Corbo,Tokio Sano,Heather Nick,Enrico Pola,Smitha P.S. Pilla,Warren C. Ladiges,Nam Vo,Johnny Huard,Laura J. Niedernhofer,Laura J. Niedernhofer,Paul D. Robbins,Paul D. Robbins +33 more
TL;DR: It is demonstrated that the ATM kinase is a major mediator of DNA damage-induced, NF-κB-mediated cellular senescence, stem cell dysfunction and aging and thus represents a therapeutic target to slow the progression of aging.
Journal Article
Surgical treatment of tuberculous spondylodiscitis.
TL;DR: Surgical indications, approaches, complications and outcomes for spinal tuberculosis are analyzed, focusing on the role of surgery as an adjuvant of effective chemotherapy in the management of selected patients.