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Amira S. Barghouthy
Researcher at Scripps Research Institute
Publications - 2
Citations - 1437
Amira S. Barghouthy is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Nucleotide excision repair & Compound heterozygosity. The author has an hindex of 2, co-authored 2 publications receiving 972 citations.
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Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes.
Takayasu Mori,Matthew J. Yousefzadeh,Maryam Faridounnia,Jessica X. Chong,Fuki M. Hisama,Louanne Hudgins,Gabriela Mercado,Erin A. Wade,Amira S. Barghouthy,Lin Lee,George M. Martin,Deborah A. Nickerson,Michael J. Bamshad,Michael J. Bamshad,Laura J. Niedernhofer,Junko Oshima +15 more
TL;DR: Molecular and cellular studies indicated that the ERCC4 variants in this patient are responsible for a phenotype consistent with a variant of CS, and massive parallel sequencing for 42 unsolved cases was performed, unable to provide biological evidence supporting the pathogenic roles of the associated ER CC4 variants.