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Heike Fuhrmann-Stroissnigg
Researcher at Scripps Research Institute
Publications - 11
Citations - 4491
Heike Fuhrmann-Stroissnigg is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Senolytic & Senescence. The author has an hindex of 10, co-authored 11 publications receiving 2922 citations. Previous affiliations of Heike Fuhrmann-Stroissnigg include Max F. Perutz Laboratories.
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Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
Cellular senescence mediates fibrotic pulmonary disease
Marissa J. Schafer,Thomas A. White,Koji Iijima,Andrew J. Haak,Giovanni Ligresti,Elizabeth J. Atkinson,Ann L. Oberg,Jodie Birch,Hanna Salmonowicz,Yi Zhu,Daniel L. Mazula,Robert W. Brooks,Heike Fuhrmann-Stroissnigg,Tamar Pirtskhalava,Y. S. Prakash,Tamara Tchkonia,Paul D. Robbins,Marie Christine Aubry,João F. Passos,James L. Kirkland,Daniel J. Tschumperlin,Hirohito Kita,Nathan K. LeBrasseur +22 more
TL;DR: It is demonstrated that early-intervention suicide-gene-mediated senescent cell ablation improves pulmonary function and physical health, although lung fibrosis is visibly unaltered, and fibrotic lung disease is mediated, in part, by senescent cells.
Journal ArticleDOI
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Yi Zhu,Tamara Tchkonia,Heike Fuhrmann-Stroissnigg,Haiming Dai,Yuanyuan Y. Ling,Michael B. Stout,Tamar Pirtskhalava,Nino Giorgadze,Kurt O. Johnson,Cory B. Giles,Jonathan D. Wren,Laura J. Niedernhofer,Paul D. Robbins,James L. Kirkland +13 more
TL;DR: The hypothesis‐driven, bioinformatics‐based approach used to discover that dasatinib (D) and quercetin (Q) are senolytic can be extended to increase the repertoire ofsenolytic drugs, including additional cell type‐specific senolytics agents.
Journal ArticleDOI
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh,Yi Zhu,Sara J. McGowan,Luise A. Angelini,Heike Fuhrmann-Stroissnigg,Ming Xu,Yuan Yuan Ling,Kendra I. Melos,Tamar Pirtskhalava,Christina L. Inman,Collin A. McGuckian,Erin A. Wade,Jonathon I. Kato,Diego Grassi,Mark A. Wentworth,Christin E. Burd,Edgar A. Arriaga,Warren Ladiges,Tamara Tchkonia,James L. Kirkland,Paul D. Robbins,Laura J. Niedernhofer +21 more
TL;DR: Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan, suggesting the feasibility to translation to human clinical studies.
Journal ArticleDOI
Identification of HSP90 inhibitors as a novel class of senolytics
Heike Fuhrmann-Stroissnigg,Yuan Yuan Ling,Jing Zhao,Sara J. McGowan,Yi Zhu,Robert W. Brooks,Diego Grassi,Siobhán Q. Gregg,Jennifer L. Stripay,Akaitz Dorronsoro,Lana Corbo,Priscilla Tang,Christina Bukata,Nadja Ring,Mauro Giacca,Xuesen Li,Tamara Tchkonia,James L. Kirkland,Laura J. Niedernhofer,Paul D. Robbins +19 more
TL;DR: Treatment of Ercc1−/∆ mice, a mouse model of a human progeroid syndrome, with the HSP90 inhibitor 17-DMAG extended healthspan, delayed the onset of several age-related symptoms and reduced p16INK4a expression, demonstrating the utility of a senescence associated β-galactosidase assay as a screening platform to rapidly identify drugs that specifically affect senescent cells.