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Deborah A. Hursh
Researcher at Center for Biologics Evaluation and Research
Publications - 30
Citations - 2095
Deborah A. Hursh is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Decapentaplegic & Gene. The author has an hindex of 17, co-authored 28 publications receiving 2012 citations. Previous affiliations of Deborah A. Hursh include Johns Hopkins University School of Medicine & American University.
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Journal ArticleDOI
Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF
Marc van de Wetering,Robert Cavallo,Dennis Dooijes,Moniek van Beest,Johan H. van Es,Joseph Loureiro,Arne Ypma,Deborah A. Hursh,Tamara L. Jones,Amy Bejsovec,Mark Peifer,Mark A. Mortin,Hans Clevers +12 more
TL;DR: A maternally expressed Drosophila TCF family member is cloned, dTCF, which mediates Wingless signaling as a bipartite transcription factor and binds a canonical TCF DNA motif and interacts with the beta-catenin homolog Armadillo.
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Cross regulation of decapentaplegic and Ultrabithorax transcription in the embryonic visceral mesoderm of Drosophila
TL;DR: It is concluded that dpp both responds to and regulates Ubx in ps7 of the visceral mesoderm and that Ubx autoregulation within this tissue may be indirect as it requires more components than have previously been thought.
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Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm.
TL;DR: The regulation of decapentaplegic (dpp), a transforming growth factor (TGF)‐beta superfamily member, is analyzed and it is found that the Ultrabithorax (Ubx) HOM protein directly activates dpp expression in parasegment 7 (PS7) of the embryonic visceral mesoderm.
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A sea urchin gene encodes a polypeptide homologous to epidermal growth factor
TL;DR: RNA gel blot hybridization showed a unique temporal pattern of expression of this gene during embryogenesis and transcript enrichment in the embryonic ectoderm, suggesting that this member of the epidermal growth factor gene family plays a role in early development decisions in sea urchin embryos.
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Chromosomal stability of mesenchymal stromal cells during in vitro culture.
Brian G. Stultz,Kathleen McGinnis,Elaine E. Thompson,Jessica L. Lo Surdo,Steven R. Bauer,Deborah A. Hursh +5 more
TL;DR: Karyotyping of MSCs reveals characteristics which may be valuable in deciding the suitability of cells for further use, and indicates that chromosomal abnormalities exist in M SCs at early passages and can be clonally propagated.