D
Deborah C. Rice
Researcher at United States Department of Health and Human Services
Publications - 4
Citations - 494
Deborah C. Rice is an academic researcher from United States Department of Health and Human Services. The author has contributed to research in topics: Amyloid precursor protein & Gene. The author has an hindex of 3, co-authored 4 publications receiving 456 citations.
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Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD
Jinfang Wu,Md. Riyaz Basha,Brian Brock,David P. Cox,Fernando Cardozo-Pelaez,Christopher A. McPherson,Jean Harry,Deborah C. Rice,Bryan Maloney,Demao Chen,Debomoy K. Lahiri,Nasser H. Zawia +11 more
TL;DR: It is reported that the expression of AD-related genes as well as their transcriptional regulator were elevated in aged (23-year-old) monkeys exposed to Pb as infants, suggesting that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD.
Journal ArticleDOI
Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice.
Remi Dosunmu,Jinfang Wu,Lina Adwan,Bryan Maloney,Riyaz Basha,Christopher A. McPherson,G. Jean Harry,Deborah C. Rice,Nasser H. Zawia,Debomoy K. Lahiri +9 more
TL;DR: Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing, important for selecting appropriate models for AD and other age-related diseases.
Journal ArticleDOI
Co-localization and Distribution of Cerebral APP and SP1 and its Relationship to Amyloidogenesis
Brian Brock,Riyaz Basha,Katie DiPalma,Amy Anderson,G. Jean Harry,Deborah C. Rice,Bryan Maloney,Debomoy K. Lahiri,Nasser H. Zawia +8 more
TL;DR: Overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin and suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene.
Lifespan profiles of Alzheimer's disease–associated genes and their products in monkeys and mice.
Remi Dosunmu,Jinfang Wu,Lina Adwan,Bryan Maloney,Riyaz Basha,Christopher A. McPherson,G. Jean Harry,Deborah C. Rice,Nasser H. Zawia,Debomoy K. Lahiri +9 more
TL;DR: Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing, important for selecting appropriate models for AD and other age–related diseases.