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Deborah E. McFadden
Researcher at University of British Columbia
Publications - 63
Citations - 4334
Deborah E. McFadden is an academic researcher from University of British Columbia. The author has contributed to research in topics: DNA methylation & Trisomy. The author has an hindex of 32, co-authored 63 publications receiving 4036 citations. Previous affiliations of Deborah E. McFadden include Boston Children's Hospital & Family Research Institute.
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Journal ArticleDOI
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma
TL;DR: A novel recurrent t(12;15)(p13;q25) rearrangement in CFS is reported that may underlie the distinctive biological properties of this tumour and ETV6-NTRK3 gene fusions provide a potential diagnostic marker for CFS.
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Evidence for multi‐site closure of the neural tube in humans
Margot I. Van Allen,Dagmar K. Kalousek,Gerold F. Chernoff,Diana M. Juriloff,Muriel J. Harris,Barbara McGillivray,Siu-Li Yong,Sylvie Langlois,Patrick MacLeod,David Chitayat,Jan M. Friedman,R. Doug Wilson,Deborah E. McFadden,J T Pantzar,Susan Ritchie,Judith G. Hall +15 more
TL;DR: With the multi-site NT closure model, it is found that the majority of NTDs can be explained by failure of fusion of one of the closures or their contiguous neuropores.
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Slug is a direct Notch target required for initiation of cardiac cushion cellularization
Kyle Niessen,Yang Xin Fu,Yang Xin Fu,Linda Chang,Pamela A. Hoodless,Pamela A. Hoodless,Deborah E. McFadden,Aly Karsan,Aly Karsan +8 more
TL;DR: The data suggest that combined expression of Slug and Snail is required for EMT in cardiac cushion morphogenesis, and activation of Notch in the context of TGF-β stimulation results in synergistic up-regulation of Snail in endothelial cells.
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DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia.
Ryan K. C. Yuen,Maria S. Peñaherrera,Peter von Dadelszen,Deborah E. McFadden,Wendy P. Robinson +4 more
TL;DR: The results suggest that gene-specific hypomethylation may be a common phenomenon in EOPet placentas, and that TIMP3 could serve as a potential prenatal diagnostic marker for EOPET.
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Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia
John D. Blair,Ryan K. C. Yuen,Ryan K. C. Yuen,Brendan K. Lim,Deborah E. McFadden,Peter von Dadelszen,Peter von Dadelszen,Wendy P. Robinson,Wendy P. Robinson +8 more
TL;DR: There are widespread DNA methylation alterations in EOPET that may be associated with changes in placental function, and this property may provide a useful tool for early screening of such placentas, according to this study.