D
Debra A. Schmitz
Researcher at University of California, Los Angeles
Publications - 40
Citations - 5157
Debra A. Schmitz is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Metabolite & Particulates. The author has an hindex of 21, co-authored 40 publications receiving 4830 citations. Previous affiliations of Debra A. Schmitz include Oklahoma State University Center for Health Sciences.
Papers
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Journal ArticleDOI
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage.
Ning Li,Constantinos Sioutas,Arthur K. Cho,Debra A. Schmitz,Chandan Misra,Joan M. Sempf,Meiying Wang,Terry D. Oberley,John R. Froines,Andre E. Nel +9 more
TL;DR: The studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria.
Journal ArticleDOI
Redox activity of airborne particulate matter at different sites in the Los Angeles Basin.
Arthur K. Cho,Constantinos Sioutas,Constantinos Sioutas,Antonio H. Miguel,Yoshito Kumagai,Yoshito Kumagai,Debra A. Schmitz,Manisha Singh,Manisha Singh,Arantza Eiguren-Fernandez,John R. Froines +10 more
TL;DR: It is found that PM will catalyze the reduction of oxygen and the distribution and chemical characteristics of the redox activity of PM fractions collected in different sites in the Los Angeles Basin are examined.
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Nrf2 Is a Key Transcription Factor That Regulates Antioxidant Defense in Macrophages and Epithelial Cells: Protecting against the Proinflammatory and Oxidizing Effects of Diesel Exhaust Chemicals
Ning Li,Jawed Alam,M. Indira Venkatesan,Arantza Eiguren-Fernandez,Debra A. Schmitz,Emma Di Stefano,Ndaisha Slaughter,Erin Killeen,Xiaorong Wang,Aaron Huang,Meiying Wang,Antonio H. Miguel,Arthur K. Cho,Constantinos Sioutas,Constantinos Sioutas,Andre E. Nel +15 more
TL;DR: This study investigates the mechanism by which redox cycling organic chemicals, prepared from DEP, induce phase II enzyme expression as a protective response and proposes that Nrf2-mediated phase II enzymes expression protects against the proinflammatory effects of particulate pollutants in the setting of allergic inflammation and asthma.
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Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production
Georgette M. Buga,Rajan Singh,Shehla Pervin,Norma E. Rogers,Debra A. Schmitz,Christopher P. Jenkinson,Stephen D. Cederbaum,Louis J. Ignarro +7 more
TL;DR: Investigating whether induction of nitric oxide synthase (NOS) by LPS and cytokines is accompanied by sufficient arginase induction to render arginine concentrations rate limiting for high-output NO production reveals for the first time that substantial arginases activity is present constitutively in rat aortic endothelial cells.
Journal ArticleDOI
The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6).
Geoffrey T. Tucker,Martin S. Lennard,S W Ellis,HF Woods,Arthur K. Cho,L Y Lin,A. Hiratsuka,Debra A. Schmitz,T. Y. Y. Chu +8 more
TL;DR: In incubation of MDMA isomers with human liver microsomes indicated that their demethylenation is deficient in the poor metabolizer phenotype, and this may give rise to genetically-determined differences in toxicity.