D
Debra D. Donaldson
Researcher at University of California, San Francisco
Publications - 2
Citations - 2345
Debra D. Donaldson is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Receptor & T cell. The author has an hindex of 2, co-authored 2 publications receiving 2274 citations.
Papers
More filters
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Journal Article
Requirement for IL-13 independently of IL-4 in experimental asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma and selective neutralization of IL-13 ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction.