D
Dean Sheppard
Researcher at University of California, San Francisco
Publications - 368
Citations - 38194
Dean Sheppard is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Integrin & Integrin, beta 6. The author has an hindex of 101, co-authored 352 publications receiving 35085 citations. Previous affiliations of Dean Sheppard include University of Edinburgh & Children's Hospital of Philadelphia.
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Journal ArticleDOI
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
John S. Munger,Xiaozhu Huang,Hisaaki Kawakatsu,Mark J. D. Griffiths,Stephen L. Dalton,Jianfeng Wu,Jean-Francois Pittet,Naftali Kaminski,Chrystelle Garat,Michael A. Matthay,Daniel B. Rifkin,Dean Sheppard +11 more
TL;DR: In this article, Latency-Aged Peptide (LAP) was shown to be a ligand for the integrin alpha v beta 6 and that alpha-v beta 6-expressing cells induce spatially restricted activation of TGF beta 1.
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Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
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Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
Kevin K. Kim,Matthias C. Kugler,Paul J. Wolters,Liliane Robillard,Michael G. Galvez,Alexis N. Brumwell,Dean Sheppard,Harold A. Chapman +7 more
TL;DR: Alveolar epithelial cells are revealed as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis.
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The importance of race and ethnic background in biomedical research and clinical practice.
Esteban G. Burchard,Elad Ziv,Natasha E. Coyle,Scarlett Lin Gomez,Hua Tang,Andrew J Karter,Joanna L. Mountain,Eliseo J. Pérez-Stable,Dean Sheppard,Neil Risch +9 more
TL;DR: With the completion of a rough draft of the human genome, some have suggested that racial classification may not be useful for biomedical studies, since it reflects “a fairly small number of genes that describe appearance” and “there is no basis in the genetic code for race.
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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Douglas A. Kuperman,Xiaozhu Huang,Laura L. Koth,Grace H.-F. Chang,Gregory Dolganov,Zhou Zhu,Jack A. Elias,Dean Sheppard,David J. Erle +8 more
TL;DR: The results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma, including airway hyperreactivity and mucus overproduction.