Institution
Groote Schuur Hospital
Healthcare•Cape Town, South Africa•
About: Groote Schuur Hospital is a healthcare organization based out in Cape Town, South Africa. It is known for research contribution in the topics: Population & Transplantation. The organization has 1773 authors who have published 1703 publications receiving 42372 citations.
Topics: Population, Transplantation, Medicine, Health care, Cancer
Papers published on a yearly basis
Papers
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TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
Abstract: The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the α chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell–deficient mice by an IL-4 receptor α chain–dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.
1,904 citations
Verneri Anttila1, Verneri Anttila2, Brendan Bulik-Sullivan2, Brendan Bulik-Sullivan1 +717 more•Institutions (270)
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Abstract: Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
1,357 citations
Harvard University1, University of Cape Town2, King's College London3, Makerere University4, Johns Hopkins University5, University of Washington6, Carter Center7, Emory University8, University of London9, World Psychiatric Association10, University of Melbourne11, Al-Quds University12, Rutgers University13, Peking University14, University of Amsterdam15, Dow University of Health Sciences16, University of Health Sciences Lahore17, University of Ibadan18, University of Liverpool19, Public Health Foundation of India20, Wellcome Trust21, University of Oxford22, South African Medical Research Council23, Groote Schuur Hospital24
1,356 citations
TL;DR: The scale proposed involves a compartimentalized quantification of postural and stance disorders, limb ataxia, dysarthria and oculomotor disorders, in order that a subscore concerning these symptoms may be separately studied.
1,162 citations
Wellington Management Company1, Katholieke Universiteit Leuven2, The Chinese University of Hong Kong3, University Medical Center Groningen4, Leipzig University5, Stony Brook University6, Academy for Urban School Leadership7, French Institute of Health and Medical Research8, University College Hospital, Ibadan9, Shanghai Mental Health Center10, Harvard University11, Mental Health Services12, Groote Schuur Hospital13, Group Health Cooperative14
TL;DR: Given the prevalence and clinical consequences of the co-occurrence of mental and physical disorders, attention to their comorbidity should remain a clinical and research priority.
459 citations
Authors
Showing all 1785 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Pete Smith | 156 | 2464 | 138819 |
| Jean-Frederic Colombel | 147 | 1125 | 98944 |
| Dan J. Stein | 142 | 1727 | 132718 |
| Herman Waldmann | 118 | 586 | 49942 |
| Timothy D. Noakes | 110 | 701 | 39090 |
| Christos Sotiriou | 89 | 505 | 45407 |
| David K. C. Cooper | 87 | 932 | 30518 |
| Lionel H. Opie | 84 | 519 | 25964 |
| Karen Sliwa | 83 | 422 | 68902 |
| Robert P. Millar | 82 | 405 | 22465 |
| Bongani M. Mayosi | 78 | 403 | 68737 |
| Eric D. Bateman | 75 | 345 | 30999 |
| Keertan Dheda | 75 | 357 | 24757 |
| Frank Brombacher | 73 | 282 | 26440 |
| Fatima Cardoso | 71 | 411 | 28844 |