D
Debra J. Morrison
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 7
Citations - 893
Debra J. Morrison is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Transcription factor & Receptor tyrosine kinase. The author has an hindex of 7, co-authored 7 publications receiving 866 citations. Previous affiliations of Debra J. Morrison include Northwestern University.
Papers
More filters
Journal ArticleDOI
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
TL;DR: New biochemical and genetic evidence indicates specific roles of the Spry genes in development and multiple modes of action of theSpry proteins in regulation of the RTK-induced response.
Journal ArticleDOI
Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop
Jacqueline M. Mason,Debra J. Morrison,Bhramdeo Bassit,Manjari Dimri,Hamid Band,Jonathan D. Licht,Isabelle Gross +6 more
TL;DR: It is found that tyrosine phosphorylation of Sprouty2 affected neither its subcellular localization nor its interaction with Grb2, FRS2/SNT, or otherSprouty proteins, which highlights a novel negative and positive regulatory loop that allows for the controlled, homeostatic inhibition of RTK signaling.
Journal ArticleDOI
WT1 Activates a Glomerular-Specific Enhancer Identified from the Human Nephrin Gene
TL;DR: The Wilms tumor suppressor gene (WT1) is a zinc-finger-containing transcription factor that is coexpressed with NPHS1 in differentiated podocytes; gel shift binding assays demonstrate that a recombinant WT1 protein can bind and activate the 186-bp NPHS 1 fragment in a sequence-specific manner.
Journal ArticleDOI
The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development.
Isabelle Gross,Debra J. Morrison,Deborah Hyink,Kylie Georgas,Milton A. English,Mathias Mericskay,Seiyu Hosono,David Sassoon,Patricia D. Wilson,Melissa H. Little,Jonathan D. Licht +10 more
TL;DR: Sprouty1 represents a physiologically relevant target gene of WT1 during kidney development, including a homologue of the Drosophila receptor tyrosine kinase regulator, sprouty, which plays a key role in the early steps of glomerulus formation.
Journal ArticleDOI
WT1 Induces Apoptosis through Transcriptional Regulation of the Proapoptotic Bcl-2 Family Member Bak
TL;DR: The hypothesis that Wilms' tumors arise, in part, because WT1 mutant proteins fail to promote programmed cell death during kidney development is supported.