Melissa H. Little

TL;DR: The developmental mechanism regulating the preferential induction of collecting duct versus kidney mesenchyme progenitors is identified and kidney organoids that contain nephrons associated with a collecting duct network surrounded by renal interstitium and endothelial cells are generated.

TL;DR: This study has successfully directed the differentiation of human embryonic stem cells (hESCs) through posterior primitive streak and IM under fully chemically defined monolayer culture conditions using growth factors used during normal embryogenesis, resulting in the synchronous induction of UB and MM that forms a self-organizing structure, including nephron formation, in vitro.

TL;DR: The SP phenotype may prove invaluable for the initial isolation of resident tissue stem cells in the absence of definitive cell‐surface markers and may have broad‐ranging applications in stem cell biology, from the purification of novel stem cell populations to the development of autologous stem cell therapies.

TL;DR: Recent insights into central regulatory processes governing organ assembly and renal disease are focused on, and future directions for the field are predicted.

TL;DR: A role for VEGF-B in the development or function of coronary vasculature is revealed and potential clinical use in therapeutic angiogenesis is suggested.