D
Deirdre K. Luttrell
Researcher at Medical University of South Carolina
Publications - 28
Citations - 3910
Deirdre K. Luttrell is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Receptor tyrosine kinase & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 17, co-authored 28 publications receiving 3764 citations. Previous affiliations of Deirdre K. Luttrell include Research Triangle Park.
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Journal ArticleDOI
Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases
Louis M. Luttrell,Brian E. Hawes,Tim van Biesen,Deirdre K. Luttrell,Timothy J. Lansing,Robert J. Lefkowitz +5 more
TL;DR: The role of the ubiquitous nonreceptor tyrosine kinase c-Src in activation of the MAP kinase pathway via endogenous G protein-coupled lysophosphatidic acid (LPA) receptors or by transient expression of Gβγ subunits in COS-7 cells is investigated.
Journal ArticleDOI
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
T van Biesen,Brian E. Hawes,Deirdre K. Luttrell,Kathleen M. Krueger,Kazushige Touhara,E Porfiri,M Sakaue,Louis M. Luttrell,Robert J. Lefkowitz +8 more
TL;DR: It is demonstrated that activation of MAP kinase by Gi-coupled receptors is preceded by the Gβγ-mediated tyrosine phosphorylation of She, leading to an increased functional association between She, Grb2 and Sos.
Journal ArticleDOI
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
Rakesh Kumar,Victoria B. Knick,Sharon K. Rudolph,Jennifer H. Johnson,Renae M. Crosby,Ming-Chih Crouthamel,Teresa M. Hopper,Charles G. Miller,Laura E. Harrington,J. A. Onori,Robert J. Mullin,Tona M. Gilmer,Anne T. Truesdale,Andrea H. Epperly,Amogh Boloor,Jeffrey A. Stafford,Deirdre K. Luttrell,Mui Cheung +17 more
TL;DR: It is shown that the antitumor and antiangiogenic activity of VEGFR inhibitors is dependent on steady-state concentration of the compound above a threshold, which is consistent with the concentration required for the inhibition of V EGF-induced V EGFR2 phosphorylation in mouse lungs.
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Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor A SCAFFOLD FOR G PROTEIN-COUPLED RECEPTOR-MEDIATED Ras ACTIVATION
Louis M. Luttrell,Gregory J. Della Rocca,Tim van Biesen,Deirdre K. Luttrell,Robert J. Lefkowitz +4 more
TL;DR: Data suggest that Gbetagamma subunit-mediated activation of Src family nonreceptor tyrosine kinases can account for the Gi-coupled receptor-mediated tyosine phosphorylation events that direct recruitment of the Shc and Grb2 adapter proteins to the membrane.
Journal ArticleDOI
Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors CONVERGENCE OF Gi- AND Gq-MEDIATED PATHWAYS ON CALCIUM/CALMODULIN, Pyk2, AND Src KINASE
Gregory J. Della Rocca,Tim van Biesen,Yehia Daaka,Deirdre K. Luttrell,Louis M. Luttrell,Robert J. Lefkowitz +5 more
TL;DR: Results indicate that calcium-calmodulin plays a central role in the calcium-dependent regulation of tyrosine phosphorylation by G protein-coupled receptors in some systems, and indicate that in HEK-293 cells, the Gβγ subunit-mediated α2A-AR- and the Gαq/11-mediated βARK1ct-mediated Erk1/2 activation pathways converge at the level of phospholipase C.