D
Denis Hervé
Researcher at University of Paris
Publications - 91
Citations - 7268
Denis Hervé is an academic researcher from University of Paris. The author has contributed to research in topics: Dopamine & Nucleus accumbens. The author has an hindex of 41, co-authored 86 publications receiving 6969 citations. Previous affiliations of Denis Hervé include French Institute of Health and Medical Research & PSL Research University.
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Journal ArticleDOI
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
Emmanuel Valjent,Vincent Pascoli,Per Svenningsson,Surojit Paul,Hervé Enslen,Jean-Christophe Corvol,Alexandre Stipanovich,Jocelyne Caboche,Paul J. Lombroso,Angus C. Nairn,Paul Greengard,Denis Hervé,Jean-Antoine Girault +12 more
TL;DR: Activation of ERK, by a multilevel protein phosphatase-controlled mechanism, functions as a detector of coincidence of dopamine and glutamate signals converging on medium-size striatal neurons and is critical for long-lasting effects of drugs of abuse.
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Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol.
Jesus Bertran-Gonzalez,Clémentine Bosch,Matthieu Maroteaux,Miriam Matamales,Denis Hervé,Emmanuel Valjent,Jean-Antoine Girault +6 more
TL;DR: It is demonstrated that cocaine and haloperidol specifically activate signaling pathways in two completely segregated populations of striatal output neurons, providing direct evidence for the selective mechanisms by which these drugs exert their long-term effects.
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Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.
TL;DR: The results outline a subset of structures in which ERK activation might specifically contribute to the long‐term effects of drugs of abuse, and suggest mapping ERKactivation in brain as a way to identify potential sites of action of psychoactive drugs.
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Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in l-DOPA-Induced Dyskinesia
Emanuela Santini,Emmanuel Valjent,Alessandro Usiello,Manolo Carta,Anders Borgkvist,Jean-Antoine Girault,Denis Hervé,Paul Greengard,Gilberto Fisone +8 more
TL;DR: A significant proportion of the abnormal involuntary movements developed in response to chronic l-DOPA are attributable to hyperactivation in striatal medium spiny neurons of a signaling pathway including sequential phosphorylation of DARPP-32, ERK1/2, MSK-1, and histone H3.
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Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat
S. Lavielle,Jean-Pol Tassin,A.M. Thierry,G. Blanc,Denis Hervé,Catherine Barthélémy,Jacques Glowinski +6 more
TL;DR: Using the DOPAC/DA ratio as an index of the activity of the neurons, the mesocortical dopaminergic neurons were found to be selectively activated under stress since this ratio was increased in the frontal and cingular cortices but not in limbic structures such as the septum, the amygdala and the nucleus accumbens.