Denise M. Monack

TL;DR: A positive selection microfluidic-based genetic screen that allows us to identify Salmonella virulence factors that manipulate dendritic cell (DC) migration within stable, linear chemokine gradients is developed.

TL;DR: It is demonstrated that urease is not essential for B. bronchiseptica colonization of the guinea‐pig respiratory and digestive tracts.

TL;DR: System-wide manipulation of neutrophil numbers revealed that neutrophils regulated signal transducer and activator of transcription (STAT) signaling in B cells during infection, which enacts a coordinated response when faced with complex environmental and pathogenic perturbations.

TL;DR: Poor glycaemic control impaired innate responses during the early stages of B. pseudomallei acute infection, contributing to the increased susceptibility of STZ‐induced diabetics to this fatal disease.

TL;DR: A combined, single-cell approach reveals that NF-κB and MAPK signaling dynamics are sufficient to discriminate between pathogen-associated molecular patterns (PAMPs) versus bacteria, extracellular versus intracellular bacteria, pathogenic versus non-pathogenic bacteria, and the presence or absence of features indicating an active intrACEllular bacterial infection.