D
Denise M. Monack
Researcher at Stanford University
Publications - 152
Citations - 24804
Denise M. Monack is an academic researcher from Stanford University. The author has contributed to research in topics: Innate immune system & Inflammasome. The author has an hindex of 73, co-authored 145 publications receiving 22245 citations. Previous affiliations of Denise M. Monack include Rocky Mountain Laboratories & University of California, Los Angeles.
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Journal ArticleDOI
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection
TL;DR: It is reported that the cytosolic DNA sensors, cyclic GMP-AMP synthase (cGAS) and Ifi204, are both required for the STING-dependent type I IFN response to F. novicida infection, and that dsDNA from F.Novicida is an important type IIFN stimulating ligand.
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virK, somA and rcsC are important for systemic Salmonella enterica serovar Typhimurium infection and cationic peptide resistance
TL;DR: It is concluded that virK, somA and rcsC are important for late stages of Salmonella enteric fever, and that they probably contribute to the remodelling of the bacterial outer membrane in response to the host environment.
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The bvgAS locus negatively controls motility and synthesis of flagella in Bordetella bronchiseptica.
TL;DR: A phenotype in Bordetella bronchiseptica that is negatively controlled by bvg is identified and the biphasic nature of the B. bronchisesptica bvg regulon is highlighted to provide a preliminary characterization of the bvg-regulated motility phenotype.
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Type I IFN Signaling Constrains IL-17A/F Secretion by γδ T cells during Bacterial Infections
Thomas Henry,Girish S. Kirimanjeswara,Thomas Ruby,Jonathan W. Jones,Kaitian Peng,Magali Perret,Lena Ho,John-Demian Sauer,Yoichiro Iwakura,Dennis W. Metzger,Denise M. Monack +10 more
TL;DR: The results indicate that the type I IFN-mediated negative regulation of IL-17A+ γδ T cell expansion is conserved during bacterial infections.
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Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
Laura E. Sanman,Yu Qian,Nicholas A Eisele,Tessie M Ng,Wouter A. van der Linden,Denise M. Monack,Eranthie Weerapana,Matthew Bogyo +7 more
TL;DR: The identification of an intracellular trigger of NLRP3-mediated inflammatory signaling, IL-1β production and pyroptosis in primed murine bone marrow-derived macrophages that is mediated by the disruption of glycolytic flux is described.