D
Denise M. Monack
Researcher at Stanford University
Publications - 152
Citations - 24804
Denise M. Monack is an academic researcher from Stanford University. The author has contributed to research in topics: Innate immune system & Inflammasome. The author has an hindex of 73, co-authored 145 publications receiving 22245 citations. Previous affiliations of Denise M. Monack include Rocky Mountain Laboratories & University of California, Los Angeles.
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Journal ArticleDOI
Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion.
Geoffrey K. Feld,Sahar El-Etr,Michele Corzett,Mark S. Hunter,Kamila Belhocine,Denise M. Monack,Matthias Frank,Brent W. Segelke,Amy Rasley +8 more
TL;DR: The results identify REP34 as an active carboxypeptidase, implicate the enzyme as a potential key F. tularensis effector protein, and may help elucidate a mechanistic understanding of F. Tularensis infection of phagocytic cells.
Journal Article
The vir locus and phase-variation in Bordetella pertussis.
TL;DR: In this article, the authors examined the state of the vir locus in each of a series of strains derived one from the other by phase-variation and found that a single base-pair change is associated with the change between the virulent and avirulent phases.
Posted ContentDOI
Single-cell profiling identifies ACE+ granuloma macrophages as a nonpermissive niche for intracellular bacteria during persistent Salmonella infection
Trung H.M. Pham,Yu Xue,Susan M. Brewer,Kenneth H. Bernstein,Stephen R. Quake,Denise M. Monack +5 more
TL;DR: It is shown that ACE+ granuloma macrophages have restricted capacity to act as a cellular niche that enables intracellular bacterial persistence, and disruption of pathogen control by neutralizing TNF preferentially depletes ACE+ macrophage in infected tissues.
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One species, different diseases: the unique molecular mechanisms that underlie the pathogenesis of typhoidal Salmonella infections.
TL;DR: In this article , the authors highlight the current state of research into understanding the pathogenesis of both nontyphoidal and typhoidal Salmonella, with a specific interest in serovar-specific traits that allow human-adapted strains of Salmonellas to cause enteric fever.
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Editorial: Protein Export and Secretion Among Bacterial Pathogens.
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