D
Dennis A. Carson
Researcher at University of California, San Diego
Publications - 429
Citations - 28102
Dennis A. Carson is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 88, co-authored 428 publications receiving 27693 citations. Previous affiliations of Dennis A. Carson include Scripps Research Institute & Wisconsin Alumni Research Foundation.
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Journal ArticleDOI
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization
Yukio Sato,Mark Roman,H Tighe,Delphine J. Lee,Maripat Corr,Minh-Duc Nguyen,Gregg J. Silverman,Martin Lotz,Dennis A. Carson,Eyal Raz +9 more
TL;DR: Although ISS are necessary for gene vaccination, they down-regulate gene expression and thus may interfere with gene replacement therapy by inducing proinflammatory cytokines.
Journal ArticleDOI
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
Mark Roman,Elena Martín-Orozco,Justin S. Goodman,Minh-Duc Nguyen,Yukio Sato,Arash Ronaghy,Richard S. Kornbluth,Douglas D. Richman,Dennis A. Carson,Eyal Raz +9 more
TL;DR: Noncoding, ISS-enriched plasmid DMAs or ISS oligonucleotides (ISS-ODNs) potently stimulate immune responses to coadministered antigens and should be given to adding noncoding DNA adjuvants to inactivated or subunit viral vaccines that, by themselves, provide only partial protection from infection.
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Effect of neuropeptides on production of inflammatory cytokines by human monocytes
TL;DR: The findings identify a potent mechanism for nervous system regulation of host defense responses in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surrounding tissues.
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Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses
Eyal Raz,Dennis A. Carson,S E Parker,Tyler B. Parr,A M Abai,G Aichinger,S H Gromkowski,M Singh,D Lew,M A Yankauckas +9 more
TL;DR: Results indicate that the cells of the skin can take up and express free foreign DNA and induce cellular and humoral immune responses against the encoded protein, and suggest that DNA uptake by the skin-associated lymphoid tissues may play a role in the induction of cytotoxic T cells against viruses and other intracellular pathogens.
Journal ArticleDOI
Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization
Eyal Raz,H Tighe,Yukio Sato,Maripat Corr,Jean Dudler,Mark Roman,Susan L. Swain,Hans L. Spiegelberg,Dennis A. Carson +8 more
TL;DR: The data demonstrate that gene immunization induces a Th1 response that dominates over an ongoing protein-induced Th2 response in an antigen-specific manner, and suggests that immunization with pDNA encoding for allergens may provide a novel type of immunotherapy for allergic diseases.