D
Dennis M. Peffley
Researcher at University of South Carolina
Publications - 30
Citations - 823
Dennis M. Peffley is an academic researcher from University of South Carolina. The author has contributed to research in topics: Reductase & 7-Dehydrocholesterol reductase. The author has an hindex of 17, co-authored 29 publications receiving 798 citations. Previous affiliations of Dennis M. Peffley include University of Tennessee Health Science Center & Jewish Hospital.
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Journal ArticleDOI
Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer.
TL;DR: The combined actions of the estimated 23,000 isoprenoid constituents of plant materials, acting in concert with other chemopreventive phytochemicals, may explain the lowered cancer risk associated with a diet rich in plant products.
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Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells.
TL;DR: Reductase mRNA was increased about eight‐fold in Caco2 human colon adenocarcinoma cells compared with that in CCD18 normal colon cells and this finding attenuates normal sterol‐mediated regulation of reductase activity.
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Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells. Apparent translational control.
TL;DR: The results are interpreted to suggest that the non-sterol mevalonate-derived regulatory product of HMG-CoA reductase acts by a translational control mechanism.
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In Vivo Expression of an Alternatively Spliced Human Tumor Message That Encodes a Truncated Form of Cathepsin B SUBCELLULAR DISTRIBUTION OF THE TRUNCATED ENZYME IN COS CELLS
Sapna Mehtani,Qiuming Gong,Jeffrey Panella,Subbalakshmi Subbiah,Dennis M. Peffley,Allen Frankfater +5 more
TL;DR: Results indicate that the message missing exons 2 and 3 is likely to be translated into a catalytically active enzyme, and that alternative splicing (exon skipping) could contribute to the aberrant intracellular trafficking of cathepsin B that is observed in some human cancers.
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Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis at the Post-Transcriptional Level
TL;DR: The results indicate that the three plant-derived isoprenoids primarily suppress H MG-CoA reductase synthesis at a post-transcriptional level by attenuating HMG- CoA reduCTase mRNA translational efficiency.