D
Deping Wang
Researcher at Biogen Idec
Publications - 7
Citations - 282
Deping Wang is an academic researcher from Biogen Idec. The author has contributed to research in topics: Infectivity & Antibody. The author has an hindex of 4, co-authored 7 publications receiving 256 citations.
Papers
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Journal ArticleDOI
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Douglas Marcotte,Weike Zeng,Jean-Christophe Hus,Andres McKenzie,C Hession,Ping Jin,Chris Bergeron,Alexey Lugovskoy,Istvan J. Enyedy,Hernan Cuervo,Hernan Cuervo,Deping Wang,Cédric Atmanene,Dominique Roecklin,Malgorzata M. Vecchi,Valérie Vivat,Joachim Kraemer,Dirk Winkler,Victor Hong,Victor Hong,Jianhua Chao,Matvey E. Lukashev,Laura Silvian +22 more
TL;DR: Several small molecule compounds that specifically bind to the Keap1 Kelch-DC domain are identified as measured by NMR, native mass spectrometry and X-ray crystallography and one compound upregulates Nrf2 response genes measured by a luciferase cell reporter assay.
Journal ArticleDOI
Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules.
Jacob L. Jordan,Jacob L. Jordan,Joseph Arndt,Karl J. M. Hanf,Guohui Li,Janine Hall,Stephen Demarest,Flora Huang,Xiufeng Wu,Brian Robert Miller,Scott Glaser,Erik J. Fernandez,Deping Wang,Alexey Lugovskoy +13 more
TL;DR: A detailed crystallographic and computational characterization of the stabilization patterns in the lymphotoxin‐beta receptor binding Fv domain of an anti‐LTβR/anti‐TNF‐related apoptosis inducing ligand receptor‐2 (TRAIL‐R2) bispecific immunoglobulin‐like antibody is presented.
Journal ArticleDOI
Structure-Guided Design of Antibodies
TL;DR: This review will focus on recent successes in using structure-guided computational methods to design antibodies and antibody-like molecules with optimized affinity and specificity to antigen and for enhancing protein stability.
Patent
Jcv neutralizing antibodies
Kenneth Simon,Thomas Cameron,Deping Wang,Joseph Arndt,Mia Rushe,Justin A. Caravella,Eric S. Day +6 more
TL;DR: In this article, a JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1 ) was described. But the authors did not specify how the antibody was used for the treatment of PML.
Patent
Inhibiteurs de tyrosine kinase de bruton
Daniel A. Erlanson,Douglas Marcotte,Gnanasambandam Kumaravel,Junfa Fan,Deping Wang,Cuervo Julio Hernan,Laura Silvian,Noel A. Powell,Minna Bui,Brian T. Hopkins,Art Taveras,Bing Guan,Patrick Conlon,Min Zhong,Tracy J. Jenkins,Daniel Scott,Alexey Alexandrovich Lugovskoy +16 more
TL;DR: In this article, the presente invention concerne des composes utiles en tant quinhibiteurs de Btk, leurs compositions and des procedes les utilisant.